Issue 9, 2016

Concise asymmetric total synthesis of catunaregin

Abstract

The asymmetric total synthesis of catunaregin isolated from the Chinese mangrove is described. The synthesis involves an asymmetric syn-selective aldol reaction and the successive ketalization of a furan diol derivative under acidic conditions. This methodology is very concise and highly stereoselective. The asymmetric total synthesis of the optically pure catunaregin was accomplished in 7 steps from a known methyl ester.

Graphical abstract: Concise asymmetric total synthesis of catunaregin

Supplementary files

Article information

Article type
Research Article
Submitted
21 5 2016
Accepted
27 6 2016
First published
28 6 2016

Org. Chem. Front., 2016,3, 1084-1086

Author version available

Concise asymmetric total synthesis of catunaregin

H. Abe, T. Hikichi, K. Emori, T. Kobayashi and H. Ito, Org. Chem. Front., 2016, 3, 1084 DOI: 10.1039/C6QO00213G

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