A photo-induced C–C bond formation methodology to construct tetrahydrofluorenones and their related structures

Abstract

A metal-free, photo-induced C–C bond formation methodology was developed to construct tetrahydrofluorenones and their related structures. This mild and efficient method proceeds either through electrocyclization or radical cyclization from β-Cl or β-Br aryl vinyl ketone. We believe that this method is particularly useful for the synthesis of related tetrahydrofluorenone containing natural products.