Issue 3, 2016

N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

Abstract

The first NHC-catalyzed dehydrogenative coupling of enals is described. With a suitable combination of NHC precatalyst, base, and solvent, the reaction proceeded smoothly to yield a wide range of monobactams. These substituted monobactams have been synthesized for the first time, and they are versatile synthetic intermediates toward other useful complex molecules.

Graphical abstract: N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

Associated articles

Supplementary files

Article information

Article type
Research Article
Submitted
14 11 2015
Accepted
05 1 2016
First published
07 1 2016

Org. Chem. Front., 2016,3, 335-338

N-Heterocyclic carbene catalyzed dehydrogenative coupling of enals: synthesis of monobactams

F. Li, C. Zhao and J. Wang, Org. Chem. Front., 2016, 3, 335 DOI: 10.1039/C5QO00372E

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