Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Kerstin Luder; Ketav Kulkarni; Huey Wen Lee; Robert E. Widdop; Mark P. Del Borgo; Marie-Isabel Aguilar

doi:10.1039/C6CC00247A

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Decorated self-assembling β³-tripeptide foldamers form cell adhesive scaffolds†

Kerstin Luder,‡^a Ketav Kulkarni,‡^a Huey Wen Lee,^b Robert E. Widdop,^b Mark P. Del Borgo*^a and Marie-Isabel Aguilar*^a

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* Corresponding authors

^a Department of Biochemistry & Molecular Biology, Monash University, Clayton, VIC, Australia
E-mail: mark.delborgo@monash.edu, mibel.aguilar@monash.edu

^b Department of Pharmacology, Monash University, Wellington Rd, Clayton, VIC, Australia

Abstract

A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.

This article is part of the themed collection: Foldamers

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Article information

DOI: https://doi.org/10.1039/C6CC00247A
Article type: Communication
Submitted: 11 1 2016
Accepted: 29 2 2016
First published: 29 2 2016

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Chem. Commun., 2016,52, 4549-4552

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Decorated self-assembling β³-tripeptide foldamers form cell adhesive scaffolds

K. Luder, K. Kulkarni, H. W. Lee, R. E. Widdop, M. P. Del Borgo and M. Aguilar, Chem. Commun., 2016, 52, 4549 DOI: 10.1039/C6CC00247A

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Chemical Communications