Issue 9, 2016
From the journal:

Chemical Communications

Foldameric probes for membrane interactions by induced β-sheet folding†

Zsófia Hegedüs,‡a   Ildikó Makra,‡b   Norbert Imre,a   Anasztázia Hetényi,c   István M. Mándity,d   Éva Monostorib  and  Tamás A. Martinek*a  

* Corresponding authors

a Institute of Pharmaceutical Analysis, SZTE-MTA Lendület Foldamer Research Group, University of Szeged, H-6720 Szeged, Hungary
E-mail: martinek@pharm.u-szeged.hu

b Lymphocyte Signal Transduction Laboratory, Institute of Genetics, Biological Research Centre of the Hungarian Academy of Sciences, H-6726 Szeged, Hungary

c Department of Medical Chemistry, University of Szeged, H-6720 Szeged, Hungary

d Institute of Pharmaceutical Chemistry, University of Szeged, H-6720 Szeged, Hungary

Abstract

Design strategies were devised for α/β-peptide foldameric analogues of the antiangiogenic anginex with the goal of mimicking the diverse structural features from the unordered conformation to a folded β-sheet in response to membrane interactions. Structure–activity relationships were investigated in the light of different β-sheet folding levels.

Graphical abstract: Foldameric probes for membrane interactions by induced β-sheet folding

  • This article is part of the themed collection: Foldamers
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Article information

DOI
https://doi.org/10.1039/C5CC09257D
Article type
Communication
Submitted
08 11 2015
Accepted
10 12 2015
First published
10 12 2015

Chem. Commun., 2016,52, 1891-1894

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Foldameric probes for membrane interactions by induced β-sheet folding

Z. Hegedüs, I. Makra, N. Imre, A. Hetényi, I. M. Mándity, É. Monostori and T. A. Martinek, Chem. Commun., 2016, 52, 1891 DOI: 10.1039/C5CC09257D

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