Issue 52, 2015

A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry

Abstract

Understanding the role of oxidative stress in disease requires real time monitoring of redox status within a cell. We report a FRET-based, ratiometric redox probe which can be applied to monitor cellular oxidative capacity using three different modalities – confocal microscopy, fluorescence lifetime imaging and flow cytometry.

Graphical abstract: A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry

Supplementary files

Article information

Article type
Communication
Submitted
23 4 2015
Accepted
29 5 2015
First published
03 6 2015

Chem. Commun., 2015,51, 10510-10513

A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry

A. Kaur, M. A. Haghighatbin, C. F. Hogan and E. J. New, Chem. Commun., 2015, 51, 10510 DOI: 10.1039/C5CC03394B

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