Issue 54, 2014

Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

Abstract

The last decade has witnessed a high demand of various synthetic approaches towards bioactive achiral diarylmethanols, diaryl and triarylmethanes and the molecules derived thereof. Their biological and therapeutical relevancy in diverse areas such as antimicrobials, infectious, cardiovascular and nervous system disorders, genital tract diseases, estrogen related disorders and bone remodeling is quite well known. These small molecules have also been the starting materials for the development of a variety of pharmaceutically important compounds. Compounds belonging to this family have not only played a leading role in the development of small molecules as therapeutically useful compounds but also have become one of the mainstays for the development of organic synthesis. However, a comprehensive review which covers their synthesis as well as their biological activity is still lacking. (Two reviews cover the synthesis of chiral diarylmethanols through asymmetric aryl transfer, and three reviews cover the photochemical properties of triarylmethanes, bioconjugation, application of trityl ions and the use of triarylmethanes as dyes.) This review describes the synthesis as well as the biological activities of this group of molecules that came up in the last fifteen years (1995–2013). The current review will cover the various approaches followed for the synthesis of achiral diarylmethanols and the strategies followed for the synthesis of achiral diaryl as well as triarylmethanes. Finally, we will also cover the bioactivities of molecules containing the diaryl and triaryl methane core.

Graphical abstract: Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

Article information

Article type
Review Article
Submitted
15 2 2014
Accepted
10 6 2014
First published
30 6 2014

RSC Adv., 2014,4, 28317-28358

Synthetic methodologies of achiral diarylmethanols, diaryl and triarylmethanes (TRAMs) and medicinal properties of diaryl and triarylmethanes-an overview

S. Mondal and G. Panda, RSC Adv., 2014, 4, 28317 DOI: 10.1039/C4RA01341G

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