Issue 7, 2014

A convenient, economical and scalable multi-gram synthesis of 1-vinylcyclopropyl 4-methylbenzenesulfonate

Abstract

We describe a practical, economical, and scalable multi-gram synthesis of 1-vinylcyclopropyl 4-methylbenzenesulfonate. This intermediate is important for the rapid and economical synthesis of alkylidenecyclopropanes, which provides access to a variety of alicyclic systems via metal-catalysed higher-order carbocyclization and cycloisomerization reactions.

Graphical abstract: A convenient, economical and scalable multi-gram synthesis of 1-vinylcyclopropyl 4-methylbenzenesulfonate

Supplementary files

Article information

Article type
Tutorial Account
Submitted
24 3 2014
Accepted
20 5 2014
First published
01 7 2014

Org. Chem. Front., 2014,1, 821-824

Author version available

A convenient, economical and scalable multi-gram synthesis of 1-vinylcyclopropyl 4-methylbenzenesulfonate

O. S. Ojo, P. A. Inglesby, D. E. Negru and P. A. Evans, Org. Chem. Front., 2014, 1, 821 DOI: 10.1039/C4QO00089G

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