Issue 60, 2014

Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

Abstract

We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules.

Graphical abstract: Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
19 4 2014
Accepted
04 6 2014
First published
06 6 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 8131-8133

Author version available

Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

G. R. Abel, B. H. Cao, J. E. Hein and T. Ye, Chem. Commun., 2014, 50, 8131 DOI: 10.1039/C4CC02900C

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