Issue 42, 2013
From the journal:

Chemical Communications

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide†

Sunil Kumara  and  Andrew D. Miranker*a  

* Corresponding authors

a Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, USA
E-mail: Andrew.Miranker@yale.edu
Fax: +1 (203) 432-5175
Tel: +1 (203) 432-8954

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

Graphical abstract: A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC41452C
Article type
Communication
Submitted
25 2 2013
Accepted
03 4 2013
First published
04 4 2013

Chem. Commun., 2013,49, 4749-4751

Permissions

Request permissions

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

S. Kumar and A. D. Miranker, Chem. Commun., 2013, 49, 4749 DOI: 10.1039/C3CC41452C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements