Issue 30, 2013
From the journal:

Chemical Communications

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system†

Shlomit Guy,a   Dvir Rotem,a   Zvi Hayouka,a   Ronen Gabizon,a   Aviad Levin,b   Limor Zemel,a   Abraham Loyter,b   Danny Porath*ac  and  Assaf Friedler*ac  

* Corresponding authors

a Institute of Chemistry, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel

b Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel

c The Harvey M. Kreuger Family Center for Nanosciene and Nanotechnology, Safra Campus, The Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel
E-mail: danny.porath@mail.huji.ac.il, assaf.friedler@mail.huji.ac.il

Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Graphical abstract: Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC40748A
Article type
Communication
Submitted
29 1 2013
Accepted
20 2 2013
First published
21 2 2013

Chem. Commun., 2013,49, 3113-3115

Permissions

Request permissions

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

S. Guy, D. Rotem, Z. Hayouka, R. Gabizon, A. Levin, L. Zemel, A. Loyter, D. Porath and A. Friedler, Chem. Commun., 2013, 49, 3113 DOI: 10.1039/C3CC40748A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements