Issue 24, 2013

Light uncages a copper complex to induce nonapoptotic cell death

Abstract

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death

Supplementary files

Article information

Article type
Communication
Submitted
13 12 2012
Accepted
04 2 2013
First published
15 2 2013

Chem. Commun., 2013,49, 2460-2462

Light uncages a copper complex to induce nonapoptotic cell death

A. A. Kumbhar, A. T. Franks, R. J. Butcher and K. J. Franz, Chem. Commun., 2013, 49, 2460 DOI: 10.1039/C3CC38927H

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