Issue 26, 2013
From the journal:

Chemical Communications

A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders†

Kimberly M. Lincoln,a   Paulina Gonzalez,a   Timothy E. Richardson,b   David A. Julovich,b   Ryker Saunders,a   James W. Simpkinsb  and  Kayla N. Green*a  

* Corresponding authors

a Department of Chemistry, Texas Christian University, 2800 S. University, Ft. Worth, USA
E-mail: kayla.green@tcu.edu
Fax: +1 817 257 5851
Tel: +1 817 257 6220

b Institute for Aging and Alzheimer's Disease Research, Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, 3500 Camp Bowie, Ft. Worth, USA
E-mail: james.simpkins@unthsc.edu
Fax: +1 817 735 2091
Tel: +1 817 735 0498

Abstract

Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character.

Graphical abstract: A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

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Article information

DOI
https://doi.org/10.1039/C2CC36808K
Article type
Communication
Submitted
31 8 2012
Accepted
17 12 2012
First published
25 2 2013

Chem. Commun., 2013,49, 2712-2714

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A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders

K. M. Lincoln, P. Gonzalez, T. E. Richardson, D. A. Julovich, R. Saunders, J. W. Simpkins and K. N. Green, Chem. Commun., 2013, 49, 2712 DOI: 10.1039/C2CC36808K

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