Issue 65, 2022

tert-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy

Abstract

A metal-free radical cyclization/dehydrogenation cascade of alkenes with aldehydes has been developed for the synthesis of 3,5-disubstituted isoxazoles in a one-pot system. This protocol features excellent functional group tolerance and operational simplicity, and is easily scaled up. The radical process is well supported by TEMPO-adducts and the intermediate β-carbonyl ketoxime.

Graphical abstract: tert-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy

Supplementary files

Article information

Article type
Communication
Submitted
18 5 2022
Accepted
14 7 2022
First published
18 7 2022

Chem. Commun., 2022,58, 9152-9155

tert-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy

L. Chen, Z. Wang, H. Liu, X. Li and B. Wang, Chem. Commun., 2022, 58, 9152 DOI: 10.1039/D2CC02823A

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