Issue 20, 2021

Facile access to foldable redox-active flavin-peptide conjugates

Abstract

A convenient approach for the synthesis of foldable redox-active flavin peptide conjugates was established. A model β-hairpin oligopeptide motif was utilized to demonstrate that azidolysine side-chains are readily functionalised with an alkyne-bearing flavine derivative. The folding equilibrium of the peptide backbone as well as the redox behaviour of the flavin moieties remains intact after the conjugation.

Graphical abstract: Facile access to foldable redox-active flavin-peptide conjugates

Supplementary files

Article information

Article type
Communication
Submitted
03 3 2021
Accepted
27 4 2021
First published
27 4 2021

Org. Biomol. Chem., 2021,19, 4483-4486

Facile access to foldable redox-active flavin-peptide conjugates

F. Stricker, J. C. Kölsch, S. B. Beil, S. Preiß, S. R. Waldvogel, T. Opatz and P. Besenius, Org. Biomol. Chem., 2021, 19, 4483 DOI: 10.1039/D1OB00414J

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