Issue 81, 2021

Enantioselective first total syntheses of the antiviral natural products xiamycins D and E

Abstract

The enantioselective first total syntheses of marine pentacyclic indolosesquiterpenoids xiamycins D (4) and E (5) have been described for the first time to the best of our knowledge. The synthetic approach was designed to feature functionalization of enantiopure Wieland–Miescher ketone, Michael addition followed by Heck-type annulation/aromatization, regioselective sp3(C–H) activation, benzylic oxidation and diastereoselective reduction.

Graphical abstract: Enantioselective first total syntheses of the antiviral natural products xiamycins D and E

Supplementary files

Article information

Article type
Communication
Submitted
25 8 2021
Accepted
17 9 2021
First published
20 9 2021

Chem. Commun., 2021,57, 10644-10646

Enantioselective first total syntheses of the antiviral natural products xiamycins D and E

D. H. Dethe and M. Shukla, Chem. Commun., 2021, 57, 10644 DOI: 10.1039/D1CC04739F

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