Issue 20, 2020

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

Abstract

A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.

Graphical abstract: A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

Supplementary files

Article information

Article type
Communication
Submitted
10 1 2020
Accepted
28 2 2020
First published
02 3 2020

Nanoscale, 2020,12, 10939-10943

A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery

D. Zhao, G. Yang, Q. Liu, W. Liu, Y. Weng, Y. Zhao, F. Qu, L. Li and Y. Huang, Nanoscale, 2020, 12, 10939 DOI: 10.1039/D0NR00301H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements