Issue 6, 2020

Ni-Catalyzed reductive amination of phenols with ammonia or amines into cyclohexylamines

Abstract

Phenol and its derivatives, which naturally occur in lignocellulose, can be considered as a renewable feedstock not only for aromatic, but also for alicyclic compounds, such as primary and N-substituted cyclohexylamines. So far, the latter are mostly produced from non-renewable starting materials like benzene via problematic nitration/reduction or cross-coupling routes. Herein, an efficient reductive amination of phenol with ammonia or amines is demonstrated, for the first time without the need for rare and expensive noble metals and without using any additives. Various supported Ni catalysts were screened and we elucidated the influence of the key parameters, including the acid–base properties of the supporting material. Acquired knowledge was then applied to different phenol–ammonia/amine combinations, resulting in the synthesis of various primary, secondary and tertiary cyclohexylamines in fair to very high yields.

Graphical abstract: Ni-Catalyzed reductive amination of phenols with ammonia or amines into cyclohexylamines

Supplementary files

Article information

Article type
Paper
Submitted
26 7 2019
Accepted
18 2 2020
First published
18 2 2020

Green Chem., 2020,22, 1884-1893

Ni-Catalyzed reductive amination of phenols with ammonia or amines into cyclohexylamines

T. Cuypers, T. Morias, S. Windels, C. Marquez, C. Van Goethem, I. Vankelecom and D. E. De Vos, Green Chem., 2020, 22, 1884 DOI: 10.1039/C9GC02625H

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