Volume 222, 2020

Ultrasmall silicon nanoparticles as a promising platform for multimodal imaging

Abstract

Bimodal systems for nuclear and optical imaging are currently being intensively investigated due to their comparable detection sensitivity and the complementary information they provide. In this perspective, we have implemented both modalities on biocompatible ultrasmall silicon nanoparticles (Si NPs). Such nanoparticles are particularly interesting since they are highly biocompatible, have covalent surface functionalization and demonstrate very fast body clearance. We prepared monodisperse citrate-stabilized Si NPs (2.4 ± 0.5 nm) with more than 40 accessible terminal amino groups per particle and, for the first time, simultaneously, a near-infrared dye (IR800-CW) and a radiolabel (64Cu-NOTA = 1,4,7-triazacyclononane-1,4,7-triacetic acid) have been covalently linked to the surface of such Si NPs. The obtained nanomaterials have been fully characterized using HR-TEM, XPS, UV-Vis and FT-IR spectroscopy. These dual-labelled particles do not exhibit any cytotoxicity in vitro. In vivo studies employing both positron emission tomography (PET) and optical imaging (OI) techniques revealed rapid renal clearance of dual-labelled Si NPs from mice.

Graphical abstract: Ultrasmall silicon nanoparticles as a promising platform for multimodal imaging

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
25 9 2019
Accepted
11 10 2019
First published
11 10 2019

Faraday Discuss., 2020,222, 362-383

Ultrasmall silicon nanoparticles as a promising platform for multimodal imaging

G. Singh, John L. Z. Ddungu, N. Licciardello, R. Bergmann, L. De Cola and H. Stephan, Faraday Discuss., 2020, 222, 362 DOI: 10.1039/C9FD00091G

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