Issue 7, 2019

Natural products targeting strategies involving molecular networking: different manners, one goal

Abstract

Covering: up to 2019

Landmark advances in bioinformatics tools have recently enhanced the field of natural products research, putting today's natural product chemists in the enviable position of being able to perform the efficient targeting/discovery of previously undescribed molecules by expediting the prioritization of the isolation workflow. Among these advances, MS/MS molecular networking has appeared as a promising approach to dereplicate complex natural product mixtures, leading to a real revolution in the “art of natural product isolation” by accelerating the pace of research of this field. This review illustrates through selected cornerstone studies the new thinking in natural product isolation by drawing a parallel between the different underlying philosophies behind the use of molecular networking in targeting natural products.

Graphical abstract: Natural products targeting strategies involving molecular networking: different manners, one goal

Article information

Article type
Review Article
Submitted
29 1 2019
First published
29 5 2019

Nat. Prod. Rep., 2019,36, 960-980

Natural products targeting strategies involving molecular networking: different manners, one goal

A. E. Fox Ramos, L. Evanno, E. Poupon, P. Champy and M. A. Beniddir, Nat. Prod. Rep., 2019, 36, 960 DOI: 10.1039/C9NP00006B

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