Issue 86, 2019

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

Abstract

A visible light-mediated α-functionalization of 1,3-dicarbonyl compounds with switchable selectivity induced by disulfide is disclosed. Upon irradiation with visible light, the metal- and base-free α-hydroxylation or α-hydroxymethylation reaction proceeded smoothly through a disulfide-catalyzed oxidation under mild conditions. The combination of a continuous-flow strategy could further improve the reaction efficiencies.

Graphical abstract: Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

Supplementary files

Article information

Article type
Communication
Submitted
23 8 2019
Accepted
07 10 2019
First published
07 10 2019

Chem. Commun., 2019,55, 13008-13011

Visible light-mediated selective α-functionalization of 1,3-dicarbonyl compounds via disulfide induced aerobic oxidation

J. Zhao, F. Yang, Z. Yu, X. Tang, Y. Wu, C. Ma and Q. Meng, Chem. Commun., 2019, 55, 13008 DOI: 10.1039/C9CC06544J

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