Issue 34, 2017

Molecular imaging probes for multi-spectral optoacoustic tomography

Abstract

Multi-Spectral Optoacoustic Tomography (MSOT) merges the power of high-resolution imaging at tissue depths of several millimeters to centimeters with the advantages of optical imaging, in large part by exploiting spectral detection of endogenous molecules in tissue or exogenous photoabsorbing probes. Current advances in fast-tuning laser technology, image reconstruction and spectral detection schemes have yielded real-time optoacoustic (photoacoustic) imaging spanning applications from microscopy to human imaging. This progress has generated an unprecedented need for imaging probes and reporter gene approaches optimized for optoacoustic signal generation. New classes of probes are emerging and create new opportunities for visualizing morphological and pathophysiological features in vivo, in a non-invasive manner. Here we review recent progress in optoacoustic probes and discuss applications and challenges for biological imaging as well as prospects for clinical translation.

Graphical abstract: Molecular imaging probes for multi-spectral optoacoustic tomography

Article information

Article type
Feature Article
Submitted
25 11 2016
Accepted
30 3 2017
First published
30 3 2017

Chem. Commun., 2017,53, 4653-4672

Molecular imaging probes for multi-spectral optoacoustic tomography

V. Gujrati, A. Mishra and V. Ntziachristos, Chem. Commun., 2017, 53, 4653 DOI: 10.1039/C6CC09421J

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