Issue 38, 2014

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Abstract

An improved, Weinreb amide-based, synthesis of anti-trypanosomal lysine-containing vinyl sulfones is described incorporating, as a feature, diversity at the ε-lysine amino group. Members of this family demonstrated moderate to good efficacy as anti-trypanosomal agents and a fluorescent dansyl (19) derivative was used to investigate subcellular localisation of the compound class.

Graphical abstract: Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

Supplementary files

Article information

Article type
Paper
Submitted
07 7 2014
Accepted
12 8 2014
First published
12 8 2014

Org. Biomol. Chem., 2014,12, 7561-7571

Author version available

Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones

W. Doherty, J. James, P. Evans, L. Martin, N. Adler, D. Nolan and A. Knox, Org. Biomol. Chem., 2014, 12, 7561 DOI: 10.1039/C4OB01412J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements