Issue 24, 2013
From the journal:

Chemical Communications

Light uncages a copper complex to induce nonapoptotic cell death†

Anupa A. Kumbhar,ab   Andrew T. Franks,a   Raymond J. Butcherc  and  Katherine J. Franz*a  

* Corresponding authors

a Duke University, Dept. of Chemistry, 124 Science Dr, Durham, NC, USA
E-mail: katherine.franz@duke.edu
Fax: +1 919 660 1605
Tel: +1 919 660 1541

b Dept. of Chemistry, University of Pune, Pune-411007, India
E-mail: aak@chem.unipune.ac.in
Fax: +91 020 25691728
Tel: +91 020 25601395, Ext. 516

c Dept. of Chemistry, Howard University, Washington, DC, USA
E-mail: rbutcher@fac.howard.edu
Fax: +1 205 806 5442
Tel: +1 202 806 6886

Abstract

Cu3G is a Cu(II) complex of a photoactive tetradentate ligand that is cleaved upon UV irradiation to release Cu. Here we show that the cytotoxicity of Cu3G increases in response to brief UV stimulation to result in extensive cytoplasmic vacuolization that is indicative of nonapoptotic cell death.

Graphical abstract: Light uncages a copper complex to induce nonapoptotic cell death

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Article information

DOI
https://doi.org/10.1039/C3CC38927H
Article type
Communication
Submitted
13 12 2012
Accepted
04 2 2013
First published
15 2 2013

Chem. Commun., 2013,49, 2460-2462

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Light uncages a copper complex to induce nonapoptotic cell death

A. A. Kumbhar, A. T. Franks, R. J. Butcher and K. J. Franz, Chem. Commun., 2013, 49, 2460 DOI: 10.1039/C3CC38927H

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