Issue 30, 2012

Methylthioxylose – a jewel in the mycobacterial crown?

Abstract

Ten years ago an unusual sugar was discovered in a cell wall polysaccharide of Mycobacterium tuberculosis. Structural elucidation revealed the presence of the first thiosugar in a bacterial polysaccharide. Synthetic studies have helped to define its relative and absolute configuration as α-D-methylthioxylofuranosyl. While its biosynthetic origins remain the subject of speculation, work has begun to define its possible biological roles.

Graphical abstract: Methylthioxylose – a jewel in the mycobacterial crown?

Article information

Article type
Perspective
Submitted
27 3 2012
Accepted
12 4 2012
First published
10 5 2012

Org. Biomol. Chem., 2012,10, 5698-5706

Methylthioxylose – a jewel in the mycobacterial crown?

W. B. Turnbull and S. A. Stalford, Org. Biomol. Chem., 2012, 10, 5698 DOI: 10.1039/C2OB25630D

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