While Resonant Acoustic Mixing (RAM) has been proposed as a scalable methodology for environmentally-friendly synthesis, notably media-free mechanochemical synthesis, the underlying reaction environment and the parameters that govern reaction control,...
Integrating 3D Electron Diffraction (3D ED) analysis into the screening workflow of multicomponent systems facilitates direct structural determination from high-throughput Resonant Acoustic Mixing (RAM). This screening method enables the investigation...
Resonant acoustic mixing (RAM) as a mechanochemical alternative to traditional SPPS processes enables efficient and scalable peptide coupling without added solvent, supporting sustainable synthesis of bioactive peptides.
Herein, resonance acoustic mixing is demonstrated as an efficient method for solvent-reduced guanidine synthesis from amines using thiourea trioxide, affording in high yields while avoiding toxic solvents, picrates, and chromatography.
We demonstrate a simple strategy to use a metal surface to directly catalyse mechanochemical reactions by Resonant Acoustic Mixing (RAM), a scalable mechanochemical methodology that uniquely eliminates the need for grinding media or bulk solvent.