Graphene Quantum Dots Attenuate TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

Na Young Park, Yunseok Heo, Ji Won Yang, Je Min Yoo, Hye Ji Jang, Ju Hee Jo, Su Jeong Park, Yuxi Lin, Joonhyeok Choi, Hyeonjin Jeon, Sun Joo Cha, Gaeun Bae, Donghoon Kim, Juhee Kim, Wade Zeno, Jong Bo Park, Noriyoshi Isozumi, Tomohide Saio, Seung Hyun Kim, Hojae Lee, Byung Hee Hong, Minyeop Nahm, Young-Ho Lee and Young Bin Hong

ACS Nano, 2025, 19, 8692
DOI: 10.1021/acsnano.4c15283

Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding

Young-Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Yuka Kamada, Katsuya Iuchi, Michiko Tajiri, Kotono Suzuki, Yan Li, Yunseok Heo, Kotone Ishii, Kenta Arai, Kazunori Ban, Mayuko Hashimoto, Shuichiro Oshita, Satoshi Ninagawa, Yoshikazu Hattori, Hiroyuki Kumeta, Airu Takeuchi, Shinji Kajimoto, Hiroya Abe, Eiichiro Mori, Takahiro Muraoka, Takakazu Nakabayashi, Satoko Akashi, Tsukasa Okiyoneda, Michele Vendruscolo, Kenji Inaba and Masaki Okumura

Nat Cell Biol, 2025, 27, 1952
DOI: 10.1038/s41556-025-01794-8

Disease–disease interactions: molecular links of neurodegenerative diseases with cancer, viral infections, and type 2 diabetes

Yuxi Lin, Je Min Yoo, Yan Li, Yunseok Heo, Masaki Okumura, Hyung-Sik Won, Michele Vendruscolo, Mi Hee Lim and Young-Ho Lee

Transl Neurodegener, 2025, 14
DOI: 10.1186/s40035-025-00507-3

Molecular mechanism and therapeutic strategy of bile acids in Alzheimer’s disease from the emerging perspective of the microbiota–gut–brain axis

Menglu Wu, Yongyi Cheng, Ruolin Zhang, Wenwen Han, Hanqi Jiang, Chenchen Bi, Ziyi Zhang, Mengfei Ye, Xiuqin Lin and Zheng Liu

Biomedicine & Pharmacotherapy, 2024, 178, 117228
DOI: 10.1016/j.biopha.2024.117228

Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity

Mingeun Kim, Yuxi Lin, Eunju Nam, Dong Min Kang, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee and Mi Hee Lim

Nat Chem Biol, 2025, 21, 1709
DOI: 10.1038/s41589-025-01987-0

Amyloid fibrils in Alzheimer's disease differently modulate sleep and cortical oscillations in mice depending on the type of amyloid

Tomomi Sanagi, Masaki Okumura, Yuxi Lin, Shingo Kanemura, Eunyoung Moon, Yunseok Heo, Keiko Takahara, Young-Ho Lee and Tomomi Tsunematsu

Biophysical Chemistry, 2026, 333, 107599
DOI: 10.1016/j.bpc.2026.107599

Distinct Aggregation Behavior of N-Terminally Truncated Aβ4–42 Over Aβ1–42 in the Presence of Zn(II)

Chanju Na, Mingeun Kim, Gunhee Kim, Yuxi Lin, Young-Ho Lee, Wojciech Bal, Eunju Nam and Mi Hee Lim

ACS Chem. Neurosci., 2025, 16, 732
DOI: 10.1021/acschemneuro.4c00831

Concentration-dependent structural transition of huntingtin protein in Huntington's disease

Ji-Na Yoo, Ha-Neul Kim, Su-Yeon Choi, Yuxi Lin, Young-Ho Lee and Min-Duk Seo

Biophysical Chemistry, 2025, 325, 107473
DOI: 10.1016/j.bpc.2025.107473