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Experimental and computational studies on the palladium-catalyzed intramolecular dearomatization, electrophilic addition, intermolecular coupling sequence

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Yohimban acetylation in Rauvolfia is mediated by a leaf-specific acetyltransferase in reserpine biosynthetic gene cluster

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Plant Physiology and Biochemistry, 2026, 230, 110714
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Unraveling the specialized metabolic pathways in medicinal plant genomes: a review

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Front. Plant Sci., 2024, 15
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Streamlined screening platforms lead to the discovery of pachysiphine synthase from Tabernanthe iboga

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Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine

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Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities

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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

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A Tight-Knit Family: The Medium-Chain Dehydrogenase/Reductases of Monoterpene Indole Alkaloid Biosynthesis

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Biochemistry, 2025, 64, 2712
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Ancient gene clusters govern the initiation of monoterpenoid indole alkaloid biosynthesis and C3 stereochemistry inversion

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Nat Commun, 2025, 16
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Systematic Analysis of Nutritional Components and Characteristics in Red-Fleshed Dragon Fruit from Different Origins Using Non-Targeted Metabolomics

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Promiscuous and regiospecific Vinca minor hydroxylases for opioid akuammine biosynthesis and monoterpenoid indole alkaloid diversification

Zhan Mai, Matthew Bailey Richardson, Scott Galeung Alexander Mann, Julia Greene, Allyson Audrey Paul, Jacob Owen Perley, Ghislain Deslongchamps and Yang Qu

Plant Physiology and Biochemistry, 2025, 223, 109841
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From natural templates to precision tools: Alkaloid-derived probes in elucidating signaling and disease biology

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UPLC-ESI-QTOF-MS assisted targeted metabolomics to study the enrichment of vinca alkaloids and related metabolites in Catharanthus roseus plants grown under controlled LED environment

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Cutting-edge plant natural product pathway elucidation

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Conserved early steps of stemmadenine biosynthesis

Mohamed O. Kamileen, Yoko Nakamura, Marlen Sigmund, Radhika Keshan, Veit Gabe, Sarah Heinicke, Maritta Kunert, Benke Hong, Ryan Alam, Gyumin Kang, Lorenzo Caputi and Sarah E. O’Connor

Journal of Biological Chemistry, 2026, 302, 111120
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Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine

Mohamed O. Kamileen, Benke Hong, Klaus Gase, Maritta Kunert, Lorenzo Caputi, Benjamin R. Lichman and Sarah E. O'Connor

Angewandte Chemie, 2025, 137
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Whole Genome Assembly and Full-Length Transcriptome Sequencing of the Uncaria rhynchophylla Provides Insights into Genetic Control of Bioactive Alkaloid Biosynthesis

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Mining and characterization of a novel cytochrome P450 MaCYP71BG22 involved in the C4-stereoselective hydroxylation of 1-deoxynojirimycin biosynthesis in mulberry leaves

Yangzhen Liao, Min Wu, Jiahe Fan, Jingqiong Wan, Xin An, Xiaolan Li, Yuan Wei and Zhen Ouyang

International Journal of Biological Macromolecules, 2024, 282, 136941
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Stereochemical insights into sarpagan and akuammiline alkaloid biosynthesis

Scott Galeung Alexander Mann, Melina Paz‐Galeano, Mohammadamin Shahsavarani, Jacob Owen Perley, Jun Guo, Jorge Jonathan Oswaldo Garza‐Garcia and Yang Qu

New Phytologist, 2025, 247, 1335
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Single-cell RNA sequencing facilitates the elucidation of the complete biosynthesis of the antidepressant hyperforin in St. John’s wort

Song Wu, Ana Luisa Malaco Morotti, Jun Yang, Ertao Wang and Evangelos C. Tatsis

Molecular Plant, 2024, 17, 1439
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From data to discovery: leveraging big data in plant natural products biosynthesis research

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The Plant Journal, 2025, 122
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Oxidation of four monoterpenoid indole alkaloid classes by three cytochrome P450 monooxygenases from Tabernaemontana litoralis

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The Plant Journal, 2024, 120, 2770
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Three cytochrome P450 enzymes consecutively catalyze the biosynthesis of furanoclerodane precursors in Salvia species

Ruoxi Lin, Haixiu Li, Yiren Xiao, Zhuo Wang, Licheng Liu, Gerhard Saalbach, Carlo Martins, Matthew Furry, Christopher D. Vanderwal, Cathie Martin and Evangelos C. Tatsis

Plant Communications, 2025, 6, 101286
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Complete biosynthesis of nicotine

Lijing Chang, Zhen Xu, Purong Deng, Ning Zhang, Tingrui He, Xinying Liu, Wenqi He, Anqi Zheng, Wenjun Hu, Mingjun Pan, Wenjuan Li, Rayko Halitschke, Ran Li, Minrui Fan, Ian T. Baldwin, Yu Zhang and Dapeng Li

Cell, 2026
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Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold

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Front. Plant Sci., 2023, 14
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An attempted oxidative coupling approach to the scholarinine A framework

Kerry E. Jones, Fernando Martínez Lara, Blane P. Zavesky and Richmond Sarpong

Tetrahedron Letters, 2024, 138, 154980
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Chromosome-level Alstonia scholaris genome unveils evolutionary insights into biosynthesis of monoterpenoid indole alkaloids

Haixia Chen, Sunil Kumar Sahu, Shujie Wang, Jia Liu, Jinlong Yang, Le Cheng, Tsan-Yu Chiu and Huan Liu

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Identification of three key enzymes involved in the biosynthesis of tetracyclic oxindole alkaloids in Uncaria rhynchophylla

Eryan Guo, Mengting Yuan, Lijun Xu, Qinjia Ren, Zihan Wang, Zixin Li, Zongyao Wu, Wenyuan Liu, Yucheng Zhao, Feng Feng and Jian Xu

Bioorganic Chemistry, 2023, 136, 106545
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Total Syntheses of (+)‐Villocarine A, (−)‐Apogeissoschizine, and (+)‐Geissoschizine

Jukiya Sakamoto, Mariko Kitajima and Hayato Ishikawa

Chemistry A European J, 2023, 29
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Collective Syntheses of Corynanthe Alkaloids Based on a Chirality-Tunable Structure Unit

Tongqi Liu, Zhenrui Huang, Shuai Cheng, Wen Chen, Xiaodong Yang and Hongbin Zhang

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Plant cytochrome P450 enzymes for bioactive metabolites biosynthesis, growth regulation, and stress adaptation

Bo Liu, Zhaoyun Song and Xiaoquan Qi

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