One-pot cascade synthesis of 2-aminomaleimides and thioaminomaleimides: an alternative fluorogenic platform capable of drug conjugation

Harendra Kumar, Aakriti Garg, Sawan Kumar, Devendra Kumar Dhaked, Sreya Gupta and Subhendu Bhowmik

Org. Biomol. Chem., 2026, 24, 811
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Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels

Léa N. C. Rochet, Calise Bahou, Jonathan P. Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J. Spears, Ioanna A. Thanasi, Baihao Shao, Lisha Zhong, Dejan-Krešimir Bučar, Abil E. Aliev, Michael J. Porter, Molly M. Stevens, James R. Baker and Vijay Chudasama

Chem. Sci., 2023, 14, 13743
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Maleimide functionalized polycaprolactone micelles for glutathione quenching and doxorubicin delivery

Godwin K. Babanyinah, Abhi Bhadran, Himanshu Polara, Hanghang Wang, Tejas Shah, Michael C. Biewer and Mihaela C. Stefan

Chem. Sci., 2024, 15, 9987
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Metal-free thiol-Michael addition for hydrogen bond-rich poly(dimethyl siloxane) networks with improved electromechanical properties and self-healing capabilities

Pavle Ramah, Liyun Yu, Anders Egede Daugaard and Anne Ladegaard Skov

RSC Appl. Polym., 2024, 2, 891
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5-Hydroxy-pyrrolone based building blocks as maleimide alternatives for protein bioconjugation and single-site multi-functionalization

Ewout De Geyter, Eirini Antonatou, Dimitris Kalaitzakis, Sabina Smolen, Abhishek Iyer, Laure Tack, Emiel Ongenae, Georgios Vassilikogiannakis and Annemieke Madder

Chem. Sci., 2021, 12, 5246
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Bis-amino maleimides: a new class of dual hydrogen bond donor for anion binding and transport

Evelyn R. Morton, Michael J. Porter, James R. Baker, Vijay Chudasama and Cally J. E. Haynes

Org. Biomol. Chem., 2025, 23, 9400
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Direct functionalization of cyclic ethers with maleimide iodides via free radial-mediated sp3 C–H activation

Xiaoyu Cheng, Baojun Li, Mengsi Zhang, Haotian Lu, Wenbo Wang, Yun Ding and Aiguo Hu

Chem. Commun., 2021, 57, 4787
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Intracellular delivery of virus-like particles using a sheddable linker

Laurel M. Hagge, Arezoo Shahrivarkevishahi, Noora M. Al-Kharji, Zhuo Chen, Olivia R. Brohlin, Ikeda Trashi, Alisia Tumac, Fabian C. Herbert, Abhinay Varma Adlooru, Hamilton Lee, Hamid Reza Firouzi, Samuel A. Cornelius, Nicole J. De Nisco and Jeremiah J. Gassensmith

J. Mater. Chem. B, 2023, 11, 7126
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Synthesis of Maleimide Derivatives and Benzo[1,4]oxetane Derivatives: a Modification Method of Amine-Containing Pharmaceuticals

Lu Yin, Meitian Fu, Sihan Zhao, Qiong Wu, Ruize Jiang and Chao Huang

J. Org. Chem., 2025, 90, 13543
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Liver Phosphoenolpyruvate Carboxykinase-1 Downregulation via siRNA-Functionalized Graphene Oxide Nanosheets Restores Glucose Homeostasis in a Type 2 Diabetes Mellitus In Vivo Model

Vishal Singh, Poonam Sagar, Sunaina Kaul, Rajat Sandhir and Nitin Kumar Singhal

Bioconjugate Chem., 2021, 32, 259
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Engineering Phages to Fight Multidrug-Resistant Bacteria

Huan Peng, Irene A. Chen and Udi Qimron

Chem. Rev., 2025, 125, 933
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An innovative stepwise activated coupling reaction for fabricating functional fluorescence probes with potential photosensitive applications

Yin Li, Dong He, Qing Wan, Ben Zhong Tang and Zhiming Wang

Sensors and Actuators B: Chemical, 2024, 412, 135725
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Bone Regeneration Using MMP-Cleavable Peptides-Based Hydrogels

Weikai Chen, Ziyang Zhou, Dagui Chen, Yinghua Li, Qin Zhang and Jiacan Su

Gels, 2021, 7, 199
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NBS-Promoted Synthesis of Maleimides by Oxidative Dearomatization of Pyrroles: Mechanistic Investigations Using Online MS in Real-Time

Ankit Kumar, Pawan K. Mishra, Abhijit Nandy, Ryan A. Altman, Shibdas Banerjee and Akhilesh K. Verma

Org. Lett., 2025, 27, 7810
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Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging

Rakesh Bam, Arutselvan Natarajan, Farbod Tabesh, Ramasamy Paulmurugan and Jeremy J. Dahl

IJMS, 2023, 24, 9048
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Equimolar Cross-Coupling Using Reactive Coiled Coils for Covalent Protein Assemblies

Hironori Takeuchi, Elee Shimshoni, Satish Gandhesiri, Andrei Loas and Bradley L. Pentelute

Bioconjugate Chem., 2024
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Substituted Maleimides: Self‐Reportable Linkers and Tags in Bioconjugation, Materials Science, and Nanotechnology

Jake E. Barker, Joshua D. Tibbetts, Calum T. J. Ferguson, Yujie Xie and Rachel K. O'Reilly

Angewandte Chemie, 2024, 136
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Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies

Alexis Lossouarn, Pierre-Yves Renard and Cyrille Sabot

Bioconjugate Chem., 2021, 32, 63
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Glycolipid‐Type Amphiphiles with a Small Anilinochloromaleimide‐Based Luminogen Exhibiting Aggregation‐Induced Emission

Naoki Tsutsumi, Akitaka Ito, Yosuke Niko, Yui Bando, Kiyonori Takahashi, Masato Ikeda, Kaori Yoneyama, Takayoshi Nakamura, Masayuki Izumi and Rika Ochi

ChemistrySelect, 2022, 7
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Thiol-thiol cross-clicking using bromo-ynone reagents

Marvin Nicque, Jan H. Meffert, Diederick Maes, Kevin Bevernaege, Mehwish Iftikhar, Olivier Zwaenepoel, Jan Gettemans, Annemieke Madder and Johan M. Winne

Nat Commun, 2025, 16
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Aqueous two-phase separation enables selective purification of mono-PEGylated human serum albumin: influence of process parameters and reagent size

Salem Alkanaimsh, Osama A. Al-Rashed and Mohamed Shaaban

Front. Chem. Eng., 2025, 7
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Electroactive Proteinoid–Quantum Dot Systems

Panagiotis Mougkogiannis and Andrew Adamatzky

Small Science, 2025, 5
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Hydrolytically Stable Maleimide-End-Functionalized Polymers for Site-Specific Protein Conjugation

Thaiesha A. Wright, Monica Sharfin Rahman, Camaryn Bennett, Madolynn R. Johnson, Henry Fischesser, Natasha Ram, Amoni Tyler, Richard C. Page and Dominik Konkolewicz

Bioconjugate Chem., 2021, 32, 2447
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A Light‐Induced Decarboxylative‐Elimination of Substituted Maleimides as a Strategy Towards Triggered Photorelease

Roshni Malde, Daniel A. Richards, Luigia Salerno, Yanbo Zhao, Kersti Karu, Vijay Chudasama and James R. Baker

Eur J Org Chem, 2023, 26
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Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation

Philipp Hartmann, Kostiantyn Bohdan, Moritz Hommrich, Fabio Juliá, Lara Vogelsang, Jürgen Eirich, Rene Zangl, Christophe Farès, Julia Beatrice Jacobs, Dwaipayan Mukhopadhyay, Johanna Marie Mengeler, Alessandro Vetere, Marie Sophie Sterling, Heike Hinrichs, Stefan Becker, Nina Morgner, Wolfgang Schrader, Iris Finkemeier, Karl-Josef Dietz, Christian Griesinger and Tobias Ritter

Nat. Chem., 2024, 16, 380
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Electrochemical Visualization of Single-Molecule Thiol Substitution with Nanopore Measurement

Chao-Nan Yang, Wei Liu, Hao-Tian Liu, Ji-Chang Zhang, Ru-Jia Yu, Yi-Lun Ying and Yi-Tao Long

ACS Meas. Sci. Au, 2024, 4, 76
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Development and Evaluation of DOTA-FAPI-Maleimide as a Novel Radiotracer for Tumor Theranostic with Extended Circulation

Lixia Feng, Wenzhu Hu, Xinying Zeng, Zheng Wei, Yu Long, Mengting Li, Si Sun, Zhide Guo, Xiaoli Lan, Xianzhong Zhang, Rongqiang Zhuang and Dawei Jiang

Mol. Pharmaceutics, 2024, 21, 4386
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Hyaluronic Acid-PEG-Based Diels–AlderIn SituForming Hydrogels for Sustained Intraocular Delivery of Bevacizumab

Blessing C. Ilochonwu, Marko Mihajlovic, Roel F. Maas-Bakker, Charis Rousou, Miao Tang, Mei Chen, Wim E. Hennink and Tina Vermonden

Biomacromolecules, 2022, 23, 2914
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A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability

Calise Bahou, Peter A. Szijj, Richard J. Spears, Archie Wall, Faiza Javaid, Afrah Sattikar, Elizabeth A. Love, James R. Baker and Vijay Chudasama

Bioconjugate Chem., 2021, 32, 672
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