Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect

Tomoya Kitakaze, Atsushi Makiyama, Rika Nakai, Yuki Kimura and Hitoshi Ashida

Food Funct., 2020, 11, 3668
DOI: 10.1039/C9FO02951F

Flavonoids as P-gp Inhibitors: A Systematic Review of SARs

Jiahua Cui, Xiaoyang Liu and Larry M.C. Chow

CMC, 2019, 26, 4799
DOI: 10.2174/0929867325666181001115225

Bioinformatic analysis of highly consumed phytochemicals as P-gp binders to overcome drug-resistance

Narges Rajaei, Ghazaleh Rahgouy, Nasrin Panahi and Nima Razzaghi-Asl

Research in Pharmaceutical Sciences, 2023, 18, 505
DOI: 10.4103/1735-5362.383706

Repurposing of quinoline alkaloids identifies their ability to enhance doxorubicin‐induced sub‐G0/G1 phase cell cycle arrest and apoptosis in cervical and hepatocellular carcinoma cells

Mohamed El‐Mesery, Axel Seher, Mohamed El‐Shafey, Mohamed El‐Dosoky and Farid A Badria

Biotech and App Biochem, 2021, 68, 832
DOI: 10.1002/bab.1999

Cardamonin inhibits the expression of P-glycoprotein and enhances the anti-proliferation of paclitaxel on SKOV3-Taxol cells

Qiuhua Ding, Peiguang Niu, Yanting Zhu, Huajiao Chen and Daohua Shi

J Nat Med, 2022, 76, 220
DOI: 10.1007/s11418-021-01583-1

Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis

Joshua Zechner, Susan M. Britza, Rachael Farrington, Roger W. Byard and Ian F. Musgrave

Life Sciences, 2022, 291, 119975
DOI: 10.1016/j.lfs.2021.119975

In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs

Ana Ferreira, Adriana O. Santos, Amílcar Falcão and Gilberto Alves

Food and Chemical Toxicology, 2018, 111, 84
DOI: 10.1016/j.fct.2017.11.004

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

Jinyun Dong, Zuodong Qin, Wei-Dong Zhang, Gang Cheng, Assaraf G. Yehuda, Charles R. Ashby, Zhe-Sheng Chen, Xiang-Dong Cheng and Jiang-Jiang Qin

Drug Resistance Updates, 2020, 49, 100681
DOI: 10.1016/j.drup.2020.100681

Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein

Ying-Tzu Chang, Yu-Chao Lin, Lijuan Sun, Wei-Chieh Liao, Charles C.N. Wang, Che-Yi Chou, Susan L. Morris-Natschke, Kuo-Hsiung Lee and Chin-Chuan Hung

Phytomedicine, 2020, 71, 153239
DOI: 10.1016/j.phymed.2020.153239

Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells

Yajing Fang, Fuqiang Liang, Mengmeng Xia, Weiwei Cao, Siyi Pan, Ting Wu and Xiaoyun Xu

Food and Chemical Toxicology, 2021, 155, 112381
DOI: 10.1016/j.fct.2021.112381

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells

Zhaolin Chen, Cheng Huang, Taotao Ma, Ling Jiang, Liqin Tang, Tianlu Shi, Shantang Zhang, Lei Zhang, Pengli Zhu, Jun Li and Aizong Shen

Phytomedicine, 2018, 43, 37
DOI: 10.1016/j.phymed.2018.03.040

Quantitative Structure–Activity Relationships for the Flavonoid-Mediated Inhibition of P-Glycoprotein in KB/MDR1 Cells

Mengmeng Xia, Yajing Fang, Weiwei Cao, Fuqiang Liang, Siyi Pan and Xiaoyun Xu

Molecules, 2019, 24, 1661
DOI: 10.3390/molecules24091661

Defying Multidrug Resistance! Modulation of Related Transporters by Flavonoids and Flavonolignans

Christopher S. Chambers, Jitka Viktorová, Kateřina Řehořová, David Biedermann, Lucie Turková, Tomáš Macek, Vladimír Křen and Kateřina Valentová

J. Agric. Food Chem., 2020, 68, 1763
DOI: 10.1021/acs.jafc.9b00694

Ellagic Acid and Schisandrins: Natural Biaryl Polyphenols with Therapeutic Potential to Overcome Multidrug Resistance in Cancer

Sabesan Yoganathan, Anushan Alagaratnam, Nikita Acharekar and Jing Kong

Cells, 2021, 10, 458
DOI: 10.3390/cells10020458

Antioxidants by nature: an ancient feature at the heart of flavonoids' multifunctionality

Giovanni Agati, Cecilia Brunetti, Luana Beatriz dos Santos Nascimento, Antonella Gori, Ermes Lo Piccolo and Massimiliano Tattini

New Phytologist, 2025, 245, 11
DOI: 10.1111/nph.20195

An Integrated Computational and Experimental Framework for Investigating Flavonoid-driven Bioenhancement of Curcumin

Pooja Mallya, Mangala Shenoy K, Dani Lakshman Yarlagadda, Suvarna G Kini and Shaila A Lewis

J Pharm Innov, 2025, 20
DOI: 10.1007/s12247-025-10042-3

Efficacy of Flavonoids in Combating Fluconazole Resistant Oral Candidiasis

Dipti Srivastava, Aarti Yadav, Salma Naqvi, Himani Awasthi and Zeeshan Fatima

CPD, 2022, 28, 1703
DOI: 10.2174/1381612828666220324140257

Quercetin and doxorubicin co-delivery using β-cyclodextrin nanocarrier overcomes multi-drug resistance in cancer cells via targeting Akt/NF-κB/ABCB1 signaling pathway

Charan Singh Pawar, N. Rajendra Prasad, Priya Yadav and Bindiya Dey

emergent mater., 2025, 8, 517
DOI: 10.1007/s42247-024-00845-4

The “Yin and Yang” of Natural Compounds in Anticancer Therapy of Triple-Negative Breast Cancers

Elizabeth Varghese, Samson Samuel, Mariam Abotaleb, Sohaila Cheema, Ravinder Mamtani and Dietrich Büsselberg

Cancers, 2018, 10, 346
DOI: 10.3390/cancers10100346

Adjuvant Anti-tumor Therapy with Polyphenolic Compounds: A Review

Ilgiz Gareev, Jianhao Jiang, Ozal Beylerli, Aferin Beilerli, Tatiana Ilyasova, Alina Shumadalova, Yunlong Bai, Weijie Du and Baofeng Yang

CMC, 2025, 32, 1934
DOI: 10.2174/0109298673284605240301035057

Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?

Eva F. DeRango-Adem and Jonathan Blay

Front. Pharmacol., 2021, 12
DOI: 10.3389/fphar.2021.681477

The effect of compatibility of Aconiti Radix and honey on the pharmacokinetics of five Aconitum alkaloids in rat plasma

Jiaofeng Wu, Rong Duan, Haoran Deng, Lele Li, Yunli Zhao and Zhiguo Yu

Biomedical Chromatography, 2022, 36
DOI: 10.1002/bmc.5453

Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance

Xiaofang Luo, Qiu-Xu Teng, Jin-Yun Dong, Dong-Hua Yang, Meifeng Wang, Wubliker Dessie, Jiang-Jiang Qin, Zi-Ning Lei, Jing-Quan Wang, Zuodong Qin and Zhe-Sheng Chen

Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.01208

A Review on Anticancer Profile of Flavonoids: Sources, Chemistry, Mechanisms, Structure-activity Relationship and Anticancer Activity

Suprava Shah, Rakesh Narang, Vikram Jeet Singh, Govindaiah Pilli and Surendra Kumar Nayak

CDRR, 2023, 15, 122
DOI: 10.2174/2589977515666230120144852

Tempo-phosphate as an ESR tool to study phosphate transport

Izabela Sadowska-Bartosz, Ireneusz Stefaniuk, Bogumił Cieniek and Grzegorz Bartosz

Free Radical Research, 2018, 52, 335
DOI: 10.1080/10715762.2017.1400163

Flavonoids as P-glycoprotein inhibitors for multidrug resistance in cancer: an in-silico approach

Amit Kumar, Sourav Kalra, Kailash Jangid and Vikas Jaitak

Journal of Biomolecular Structure and Dynamics, 2023, 41, 7627
DOI: 10.1080/07391102.2022.2123390

Novel oral administrated paclitaxel micelles with enhanced bioavailability and antitumor efficacy for resistant breast cancer

Ting Zhang, Jingwen Luo, Yao Fu, Hanmei Li, Rui Ding, Tao Gong and Zhirong Zhang

Colloids and Surfaces B: Biointerfaces, 2017, 150, 89
DOI: 10.1016/j.colsurfb.2016.11.024

Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Qingmei Ye, Kai Liu, Qun Shen, Qingyue Li, Jinghui Hao, Fangxuan Han and Ren-Wang Jiang

Front. Oncol., 2019, 9
DOI: 10.3389/fonc.2019.00487

Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure–activity relationships

Jie Bai, Shengyu Zhao, Xiaoqing Fan, Yonghui Chen, Xiaowen Zou, Minwan Hu, Baolian Wang, Jing Jin, Xiaojian Wang, Jinping Hu, Dan Zhang and Yan Li

Toxicology and Applied Pharmacology, 2019, 369, 49
DOI: 10.1016/j.taap.2019.02.010

Identification of flavonol derivatives inhibiting MDR1: a strategy to overcome multidrug resistance in cancer

Min-Ji Kang, Kyeong-Ryoon Lee, You-Jin Choi and Yoon-Jee Chae

Natural Product Research, 2026, 40, 1219
DOI: 10.1080/14786419.2024.2420333

Euryops pectinatus L. Flower Extract Inhibits P-glycoprotein and Reverses Multi-Drug Resistance in Cancer Cells: A Mechanistic Study

Wafaa M. Elkady, Iriny M. Ayoub, Yousra Abdel-Mottaleb, Mohamed F. ElShafie and Michael Wink

Molecules, 2020, 25, 647
DOI: 10.3390/molecules25030647

The Use of an Antioxidant Enables Accurate Evaluation of the Interaction of Curcumin on Organic Anion-Transporting Polypeptides 4C1 by Preventing Auto-Oxidation

Toshihiro Sato, Ayaka Yagi, Minami Yamauchi, Masaki Kumondai, Yu Sato, Masafumi Kikuchi, Masamitsu Maekawa, Hiroaki Yamaguchi, Takaaki Abe and Nariyasu Mano

IJMS, 2024, 25, 991
DOI: 10.3390/ijms25020991

Rutin Alleviates Breast Cancer Resistance to Tamoxifen By Downregulating ABC Transporters, Inducing ROS Generation and Resetting Redox Status

Heba Effat, Aliaa M. Radwan, Marwa Sharaky and Hamed A. Abosharaf

J Biochem & Molecular Tox, 2025, 39
DOI: 10.1002/jbt.70490

Tackling drug resistance with efflux pump inhibitors: from bacteria to cancerous cells

Rene Christena Lowrence, Selva Ganesan Subramaniapillai, Venkatasubramanian Ulaganathan and Saisubramanian Nagarajan

Critical Reviews in Microbiology, 2019, 45, 334
DOI: 10.1080/1040841X.2019.1607248

Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats

Ana Ferreira, Márcio Rodrigues, Alexandre Marques, Amílcar Falcão and Gilberto Alves

Food and Chemical Toxicology, 2017, 106, 446
DOI: 10.1016/j.fct.2017.06.015

Combating chemoresistance: Current approaches & nanocarrier mediated targeted delivery

Siuli Shaw, Subrata Kumar Pore, Dutong Liu, Tushar Kumeria, Ranu Nayak and Sudeep Bose

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2025, 1880, 189261
DOI: 10.1016/j.bbcan.2025.189261

Exploring the interaction hotspots of p-glycoprotein with herbal bioactives: In silico insights for integrative Ayurvedic therapeutics

Chandana Roy and Pratiti Ghosh

Journal of Ayurveda and Integrative Medicine, 2025, 16, 101238
DOI: 10.1016/j.jaim.2025.101238

A State-of-the-art Review and Prospective Therapeutic Applications of Prenyl Flavonoids as Chemosensitizers against Antifungal Multidrug Resistance in Candida albicans

María Daniela Santi, María Gabriela Ortega and Mariana Andrea Peralta

CMC, 2022, 29, 4251
DOI: 10.2174/0929867329666220209103538

Discovery of a novel highly potent and low-toxic jatrophane derivative enhancing the P-glycoprotein-mediated doxorubicin sensitivity of MCF-7/ADR cells

Ayitila Maimaitijiang, Bianlin Wang, Hequn Yang, Dan Tang, Yongqiang Liu and Haji Akber Aisa

European Journal of Medicinal Chemistry, 2022, 244, 114822
DOI: 10.1016/j.ejmech.2022.114822

Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells

Marcello Iriti, Robert Kubina, Andrea Cochis, Rita Sorrentino, Elena M. Varoni, Agata Kabała‐Dzik, Barbara Azzimonti, Arkadiusz Dziedzic, Lia Rimondini and Robert D. Wojtyczka

Phytotherapy Research, 2017, 31, 1529
DOI: 10.1002/ptr.5878

Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells

Ying-Tzu Chang, Charles C.N. Wang, Jiun-Yi Wang, Tsui-Er Lee, Yung-Yi Cheng, Susan L. Morris-Natschke, Kuo-Hsiung Lee and Chin-Chuan Hung

Phytomedicine, 2019, 53, 252
DOI: 10.1016/j.phymed.2018.09.008

Flavonoid compounds as reversing agents of the P-glycoprotein-mediated multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs

Ana Ferreira, Márcio Rodrigues, Ana Fortuna, Amílcar Falcão and Gilberto Alves

Food Research International, 2018, 103, 110
DOI: 10.1016/j.foodres.2017.10.010

A significant mechanism of molecular recognition between bioflavonoids and P-glycoprotein leading to herb-drug interactions

Pathomwat Wongrattanakamon, Piyarat Nimmanpipug, Busaban Sirithunyalug, Sunee Chansakaow and Supat Jiranusornkul

Toxicology Mechanisms and Methods, 2018, 28, 1
DOI: 10.1080/15376516.2017.1351506

Suaeda vermiculata Aqueous-Ethanolic Extract-Based Mitigation of CCl4-Induced Hepatotoxicity in Rats, and HepG-2 and HepG-2/ADR Cell-Lines-Based Cytotoxicity Evaluations

Salman A. A. Mohammed, Riaz A. Khan, Mahmoud Z. El-Readi, Abdul-Hamid Emwas, Salim Sioud, Benjamin G. Poulson, Mariusz Jaremko, Hussein M. Eldeeb, Mohsen S. Al-Omar and Hamdoon A. Mohammed

Plants, 2020, 9, 1291
DOI: 10.3390/plants9101291

Total synthesis and cytotoxic evaluation of 6‐C‐prenylated flavones against MCF‐7 cells

Tran Trong Binh, Nguyen Thi Thuy Luyen, Le Thi Hoa, Nguyen Khanh Hung, Nguyen Phi Linh, Cao Nhu Anh, Le Thi Phuong, Tran Le Quan and Nguyen Huy Du

Vietnam Journal of Chemistry, 2026, 64
DOI: 10.1002/vjch.70109

A computational-based approach to fabricate Ceritinib co-amorphous system using a novel co-former Rutin for bioavailability enhancement

Dani Lakshman Yarlagadda, Vullendula Sai Krishna Anand, Athira R. Nair, Swapnil J. Dengale, Sudharsan Pandiyan, Chetan H. Mehta, Suman Manandhar, Usha Y. Nayak and Krishnamurthy Bhat

European Journal of Pharmaceutics and Biopharmaceutics, 2023, 190, 220
DOI: 10.1016/j.ejpb.2023.07.019

Design, synthesis, spectral analysis and molecular docking studies of some fluorescent biodiagnostic material as potential anti cervical cancer agents

D. Premnath, M. Indiraleka, P. Mosae Selvakumar and Israel V.M.V. Enoch

Materials Today: Proceedings, 2021, 47, 776
DOI: 10.1016/j.matpr.2020.07.397

Prediction of P-glycoprotein inhibitors with machine learning classification models and 3D-RISM-KH theory based solvation energy descriptors

Vijaya Kumar Hinge, Dipankar Roy and Andriy Kovalenko

J Comput Aided Mol Des, 2019, 33, 965
DOI: 10.1007/s10822-019-00253-5

Improvement of the Intestinal Absorption of Dihydroquercetin (DHQ) by Flavonoids via Inhibiting P-Glycoprotein (P-gp)-Mediated Efflux in P-gp Overexpressed KB/MDR1 Cells and Caco-2 Monolayers

Hainan Song, Weiwei Cao, Xiushi Chen, Siqi Peng, Wenlong Sun, Xiaojun Yang, Mahmoud Salah, Mohamed A. Farag and Yajing Fang

J. Agric. Food Chem., 2026, 74, 4823
DOI: 10.1021/acs.jafc.5c12044

RETRACTED ARTICLE:Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines

S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan and D. Velmurugan

BMC Cancer, 2018, 18
DOI: 10.1186/s12885-018-5103-1

Transport and Interactions of Co-incubated Bi-functional Flavonoids through Inhibiting the Function of P-Glycoprotein (P-gp) Using KB/Multidrug-Resistant (MDR) Cells and Rat Everted Gut Sacs

Yajing Fang, Weiwei Cao, Mengmeng Xia, Siyi Pan and Xiaoyun Xu

J. Agric. Food Chem., 2022, 70, 1923
DOI: 10.1021/acs.jafc.1c07694

Quercetin overcomes colon cancer cells resistance to chemotherapy by inhibiting solute carrier family 1, member 5 transporter

Yuanyuan Zhou, Junhong Zhang, Kaili Wang, Wenchao Han, Xinying Wang, Ming Gao, Zihan Wang, Yaxin Sun, Hao Yan, Hang Zhang, Xia Xu and Dong-Hua Yang

European Journal of Pharmacology, 2020, 881, 173185
DOI: 10.1016/j.ejphar.2020.173185

MIX2: A Novel Natural Multi-Component Modulator of Multidrug-Resistance and Hallmarks of Cancer Cells

Agata M. Gawel, Marlena Godlewska, Marta Grech-Baran, Anna Stachurska and Damian Gawel

Nutrition and Cancer, 2019, 71, 334
DOI: 10.1080/01635581.2018.1560480

Formononetin Defeats Multidrug-Resistant Cancers by Induction of Oxidative Stress and Suppression of P-Glycoprotein

Ying-Tzu Chang, I-Ting Wu, Ming-Jyh Sheu, Yu-Hsuan Lan and Chin-Chuan Hung

IJMS, 2024, 25, 8471
DOI: 10.3390/ijms25158471

Jatrophane diterpenes from Euphorbia Sororia enhance chemotherapy drugs sensitivities in P-gp-induced multidrug resistance cells

Ayitila Maimaitijiang, Hequn Yang, Xiongwen Zhang, Yongqiang Liu and Dan Tang

Fitoterapia, 2025, 186, 106839
DOI: 10.1016/j.fitote.2025.106839

Enhancing glioblastoma therapy via intranasal administration of highly potent cell-penetrating peptide decorated nanoparticles

Jain Koo, Yuseon Shin, Hyewon Jeon, Jaehyun Cheong, Seongmin Cho, Chanho Park, Ee Chan Song, Jacob D. Ramsey, Chaemin Lim and Kyung Taek Oh

Journal of Controlled Release, 2025, 378, 997
DOI: 10.1016/j.jconrel.2024.12.058

Taxifolin Resensitizes Multidrug Resistance Cancer Cells via Uncompetitive Inhibition of P-Glycoprotein Function

Hsiu-Ju Chen, Yun-Lung Chung, Chia-Ying Li, Ying-Tzu Chang, Charles C. N. Wang, Hsiang-Yen Lee, Hui-Yi Lin and Chin-Chuan Hung

Molecules, 2018, 23, 3055
DOI: 10.3390/molecules23123055

Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction

Maria D. Auxtero, Susana Chalante, Mário R. Abade, Rui Jorge and Ana I. Fernandes

Pharmaceutics, 2021, 13, 124
DOI: 10.3390/pharmaceutics13010124

A Molecular Dynamic Simulation, Structural Analysis, and Ex Vivo Insights into the P-glycoprotein Mediated Interactions of Dietary Polyphenols with Cyclin-dependent Kinase Inhibitors: A Potential Strategy to Counteract Drug Efflux

Prajakta Harish Patil, Mrunal Pradeep Desai, Vullendula Sai Krishna Anand, Rajdeep Ray, G. Gautham Shenoy, Swapnil Jayant Dengale, Krishnamurthy Bhat and Jagadish Puralae Channabasavaiah

CMC, 2025, 32, 788
DOI: 10.2174/0109298673319832240829164046

The role of diet and nutraceuticals in the amelioration of multidrug resistance amongst cancer patients

Saswata Banerjee, Arpita Banerjee, Gautam Singhvi, Rajeev Taliyan and Pubali Dhar

Beni-Suef Univ J Basic Appl Sci, 2025, 14
DOI: 10.1186/s43088-025-00706-x

Unlocking the Rich Potential of a Soft Gel-Cream Enriched with Royal Jelly for Topical Use

Monica-Elisabeta Maxim, Raluca-Marieta Toma, Ludmila Aricov, Anca-Ruxandra Leonties, Aurica Precupas, Rodica Tatia and Elena Iulia Oprita

Gels, 2025, 11, 294
DOI: 10.3390/gels11040294

Natural compounds and derivatives as modulators of multidrug resistance and their mechanisms of action: recent studies in vitro, in vivo and in silico

Jessica Nayelli Sánchez-Carranza, Shawa Verónica Montes-Helguera, Adriana Valladares-Méndez, Enrique Salas-Vidal and Leticia González-Maya

Discov Appl Sci, 2024, 6
DOI: 10.1007/s42452-024-06239-9

Silymarin as a flavonoid-type P-glycoprotein inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats

Ana Ferreira, Márcio Rodrigues, Sara Meirinho, Ana Fortuna, Amílcar Falcão and Gilberto Alves

Drug and Chemical Toxicology, 2021, 44, 458
DOI: 10.1080/01480545.2019.1601736

Molybdenum Disulfide Nanocomposites for Cancer Diagnosis and Therapeutics: Biosensors, Bioimaging, and Phototherapy

Fatemeh Sasanipoor and Zhiqing Zhang

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202500655

Polyphenols, Polysaccharides, and Their Complexes from Aronia melanocarpa in the Chemoprevention of Colorectal Cancer

Karolina Niewinna, Katarzyna Owczarek, Zuzanna Senkowska and Urszula Lewandowska

Molecules, 2025, 31, 10
DOI: 10.3390/molecules31010010

ABCB1 in dermatology: roles in skin diseases and their treatment

H. J. Weng and T. F. Tsai

J Mol Med, 2021, 99, 1527
DOI: 10.1007/s00109-021-02105-y

Kaempferol-Mediated Sensitization Enhances Chemotherapeutic Efficacy of Sorafenib Against Hepatocellular Carcinoma: An In Silico and In Vitro Approach

Bhagyalakshmi Nair, Ruby John Anto, Sabitha M and Lekshmi R. Nath

Adv Pharm Bull, 2020, 10, 472
DOI: 10.34172/apb.2020.058

Exploring new Horizons in overcoming P-glycoprotein-mediated multidrug-resistant breast cancer via nanoscale drug delivery platforms

Paras Famta, Saurabh Shah, Essha Chatterjee, Hoshiyar Singh, Biswajit Dey, Santosh Kumar Guru, Shashi Bala Singh and Saurabh Srivastava

Current Research in Pharmacology and Drug Discovery, 2021, 2, 100054
DOI: 10.1016/j.crphar.2021.100054

Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study

Mohanad Diab, Amel Hamdi, Feras Al-Obeidat, Wael Hafez, Ivan Cherrez-Ojeda, Muneir Gador, Gowhar Rashid, Sana F. Elkhazin, Mahmad Anwar Ibrahim, Tarek Farag Ismail and Samar Sami Alkafaas

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1511029

Therapeutic potential of quercetin on human breast cancer in different dimensions

Neda Kasiri, Mahshid Rahmati, Leila Ahmadi, Nahid Eskandari and Hossein Motedayyen

Inflammopharmacol, 2020, 28, 39
DOI: 10.1007/s10787-019-00660-y

Phytochemical modulation of P-Glycoprotein and its gene expression in an ivermectin-resistant Haemonchus contortus isolate in vitro

Poliana Araújo Pacheco, Helder Louvandini, Rodrigo Giglioti, Bruna Costa Rodrigues Wedy, Jessica Carolina Ribeiro, Cecilia José Verissimo, Jorge Freire da Silva Ferreira, Alessandro Francisco Talamini do Amarante and Luciana Morita Katiki

Veterinary Parasitology, 2022, 305, 109713
DOI: 10.1016/j.vetpar.2022.109713

Evaluation of the Effects of Maytenus ilicifolia on the Activities of Cytochrome P450 3A and P-glycoprotein

Sara Batista do Nascimento, Mariana de Lima Nascimento, Laís Lobato de Araújo, Flávio Martins de Oliveira, Maria do Carmo Vieira, Joaquim Maurício Duarte-Almeida, João Máximo Siqueira, Isabela da Costa César, Hartmut Derendorf and Whocely Victor de Castro

CDM, 2020, 21, 281
DOI: 10.2174/1389200221666200512112718

Incorporation of natural assumption to deal with cancer

Chenmala Karthika and Raman Sureshkumar

Environ Sci Pollut Res, 2021, 28, 4902
DOI: 10.1007/s11356-020-11479-4

Pinostrobin and Tectochrysin Conquer Multidrug-Resistant Cancer Cells via Inhibiting P-Glycoprotein ATPase

I-Ting Wu, Chan-Yen Kuo, Ching-Hui Su, Yu-Hsuan Lan and Chin-Chuan Hung

Pharmaceuticals, 2023, 16, 205
DOI: 10.3390/ph16020205

Synthesis, characterization, and pharmacological evaluation of some metal complexes of quercetin as P-gp inhibitors

Kirankumar Shastrala, Sirisha Kalam, Kumaraswamy Damerakonda, Sharvana Bhava Bandaru Sheshagiri, Hitesh Kumar, Ramu Guda, Mamatha Kasula and Satish Kumar Bedada

Futur J Pharm Sci, 2021, 7
DOI: 10.1186/s43094-021-00252-0

Non-Nutritive Sweeteners Acesulfame Potassium and Sucralose Are Competitive Inhibitors of the Human P-glycoprotein/Multidrug Resistance Protein 1 (PGP/MDR1)

Laura Danner, Florian Malard, Raquel Valdes and Stephanie Olivier-Van Stichelen

Nutrients, 2023, 15, 1118
DOI: 10.3390/nu15051118

Phytochemical profiling, molecular docking, and anti-hepatocellular carcinoid bioactivity of extracts

Hamdoon A. Mohammed, Suliman A. Almahmoud, Minhajul Arfeen, Ashish Srivastava, Mahmoud Z. El-Readi, Ehab A. Ragab, Safia M. Shehata, Salman A.A. Mohammed, Ehab M. Mostafa, Hend A. El-khawaga and Riaz A. Khan

Arabian Journal of Chemistry, 2022, 15, 103950
DOI: 10.1016/j.arabjc.2022.103950

Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers

He Bao, Nanbo Zheng, Zhuanting Li and Yuan Zhi

DDDT, 2020, Volume 14, 3057
DOI: 10.2147/DDDT.S256636

Enhanced delivery of quercetin and doxorubicin using β-cyclodextrin polymer to overcome P-glycoprotein mediated multidrug resistance

Charan Singh Pawar, N. Rajendra Prasad, Priya Yadav, I.V. Muthu Vijayan Enoch, Varnitha Manikantan, Bindiya Dey and Paran Baruah

International Journal of Pharmaceutics, 2023, 635, 122763
DOI: 10.1016/j.ijpharm.2023.122763