In vitro antitumor activity of dialkylamine-1,4-naphthoquinones toward human glioblastoma multiforme cells

José Clementino-Neto, João Kaycke Sarmento da Silva, Cibelle de Melo Bastos Cavalcante, Paulo Fernando da Silva-Júnior, Cibelle Cabral David, Morgana Vital de Araújo, Carmelita Bastos Mendes, Aline Cavalcanti de Queiroz, Elaine Cristina Oliveira da Silva, Samuel Teixeira de Souza, Eduardo Jorge da Silva Fonseca, Tânia Maria Sarmento da Silva, Celso de Amorim Camara, Vivaldo Moura-Neto, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Adriana Ximenes da-Silva and Magna Suzana Alexandre-Moreira

New J. Chem., 2022, 46, 4587
DOI: 10.1039/D1NJ05915G

Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer

Katia M. Oliveira, Erica J. Peterson, Murilo C. Carroccia, Marcia R. Cominetti, Victor M. Deflon, Nicholas P. Farrell, Alzir A. Batista and Rodrigo S. Correa

Dalton Trans., 2020, 49, 16193
DOI: 10.1039/D0DT01091J

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Jinlei Bian, Xue Qian, Bang Deng, Xiaoli Xu, Xiaoke Guo, Yalou Wang, Xiang Li, Haopeng Sun, Qidong You and Xiaojin Zhang

RSC Adv., 2015, 5, 49471
DOI: 10.1039/C5RA05919D

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

Heiko Geisler, Debora Wernitznig, Michaela Hejl, Natalie Gajic, Michael A. Jakupec, Wolfgang Kandioller and Bernhard K. Keppler

Dalton Trans., 2020, 49, 1393
DOI: 10.1039/C9DT04462K

Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Emel Mataracı-Kara, Berna Özbek-Çelik, Masami Otsuka, Mikako Fujita, Mohamed O. Radwan and Amaç Fatih TuYuN

RSC Adv., 2022, 12, 20507
DOI: 10.1039/D2RA02136F

High-yielding regioselective synthesis of p-quinone fused 5-substituted-1,4-benzodiazepine scaffolds via Pictet–Spengler type cycloannulation

Ashokkumar Krishnan and Sriraghavan Kamaraj

New J. Chem., 2024, 48, 10045
DOI: 10.1039/D4NJ00993B

Functional mixed metal oxide nanomaterials: a comprehensive review of their hyperthermic potential in cancer therapy

Amol B. Pandhare, Swapnajit V. Mulik, Santosh S. Patil, Roman V. Smotraiev, Rajendra P. Patil and Sagar D. Delekar

New J. Chem., 2025, 49, 4735
DOI: 10.1039/D4NJ02783C

Molecular hybridization as a powerful tool towards multitarget quinoidal systems: synthesis, trypanocidal and antitumor activities of naphthoquinone-based 5-iodo-1,4-disubstituted-, 1,4- and 1,5-disubstituted-1,2,3-triazoles

Samara Ben B. B. Bahia, Wallace J. Reis, Guilherme A. M. Jardim, Francielly T. Souto, Carlos A. de Simone, Claudia C. Gatto, Rubem F. S. Menna-Barreto, Solange L. de Castro, Bruno C. Cavalcanti, Claudia Pessoa, Maria H. Araujo and Eufrânio N. da Silva Júnior

Med. Chem. Commun., 2016, 7, 1555
DOI: 10.1039/C6MD00216A

One-pot synthesis of pyrimidine linked naphthoquinone-fused pyrroles by iodine-mediated multicomponent reactions

Anoop Kumar Panday, Danish Ali and Lokman H. Choudhury

Org. Biomol. Chem., 2020, 18, 4997
DOI: 10.1039/D0OB00591F

Cellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands

Cynthia Griffith, Adam S. Dayoub, Thamara Jaranatne, Nagham Alatrash, Ali Mohamedi, Kenneth Abayan, Zachary S. Breitbach, Daniel W. Armstrong and Frederick M. MacDonnell

Chem. Sci., 2017, 8, 3726
DOI: 10.1039/C6SC04094B

Effect of substituents and chain length in amino-1,4-naphthoquinones on glutathione-S-transferase inhibition: molecular docking and electrochemical perspectives: a structure–activity study

Judith Faúndes, Michelle Muñoz-Osses, Pilar Morales, Federico Tasca, César Zúñiga Loyola, Mario Faúndez, Carolina Mascayano and Juana A. Ibacache

New J. Chem., 2022, 46, 21648
DOI: 10.1039/D2NJ04079D

Synthesis and biological evaluation of novel fluorinated anticancer agents incorporating the indolin-2-one moiety

Shuai-Yu Wang, Li-Jun Wang, Bo Jiang, Ning Wu, Xiang-Qian Li, Jiao Luo, Bao-Cheng Wang, Ren-Shuai Zhang, Qi Xu and Da-Yong Shi

RSC Adv., 2015, 5, 91795
DOI: 10.1039/C5RA19617E

1,2,4-Triazolo[4,3-c]quinazolines: a bioisosterism-guided approach towards the development of novel PCAF inhibitors with potential anticancer activity

Mohamed H. El-Shershaby, Adel Ghiaty, Ashraf H. Bayoumi, Hany E. A. Ahmed, Mona S. El-Zoghbi, Khaled El-Adl and Hamada S. Abulkhair

New J. Chem., 2021, 45, 11136
DOI: 10.1039/D1NJ00710F

Sustainable chromic acid oxidation: solar-driven recycling of hexavalent chromium ions for quinone production by WO3nanosponge photoanodes

Tomohiko Nakajima, Megumi Kanaori, Aya Hagino, Hiroyuki Tateno, Tetsuo Tsuchiya and Kazuhiro Sayama

J. Mater. Chem. A, 2018, 6, 110
DOI: 10.1039/C7TA08001H

IntroducingN-,P-, andS-donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes

Sophia Harringer, Debora Wernitznig, Natalie Gajic, Andreas Diridl, Dominik Wenisch, Michaela Hejl, Michael A. Jakupec, Sarah Theiner, Gunda Koellensperger, Wolfgang Kandioller and Bernhard K. Keppler

Dalton Trans., 2020, 49, 15693
DOI: 10.1039/D0DT03165H

It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity

Daisy J. B. Lima, Renata G. Almeida, Guilherme A. M. Jardim, Breno P. A. Barbosa, Augusto C. C. Santos, Wagner O. Valença, Marcos R. Scheide, Claudia C. Gatto, Guilherme G. C. de Carvalho, Pedro M. S. Costa, Claudia Pessoa, Cynthia L. M. Pereira, Claus Jacob, Antonio L. Braga and Eufrânio N. da Silva Júnior

RSC Med. Chem., 2021, 12, 1709
DOI: 10.1039/D1MD00168J

A new strategy for site-specific alkylation of DNA using oligonucleotides containing an abasic site and alkylating probes

Norihiro Sato, Genichiro Tsuji, Yoshihiro Sasaki, Akira Usami, Takuma Moki, Kazumitsu Onizuka, Ken Yamada and Fumi Nagatsugi

Chem. Commun., 2015, 51, 14885
DOI: 10.1039/C5CC03915K

On the investigation of hybrid quinones: synthesis, electrochemical studies and evaluation of trypanocidal activity

Guilherme A. M. Jardim, Wallace J. Reis, Matheus F. Ribeiro, Flaviano M. Ottoni, Ricardo J. Alves, Thaissa L. Silva, Marilia O. F. Goulart, Antonio L. Braga, Rubem F. S. Menna-Barreto, Kelly Salomão, Solange L. de Castro and Eufrânio N. da Silva Júnior

RSC Adv., 2015, 5, 78047
DOI: 10.1039/C5RA16213K

Towards targeting anticancer drugs: ruthenium(ii)–arene complexes with biologically active naphthoquinone-derived ligand systems

Mario Kubanik, Wolfgang Kandioller, Kunwoo Kim, Robert F. Anderson, Erik Klapproth, Michael A. Jakupec, Alexander Roller, Tilo Söhnel, Bernhard K. Keppler and Christian G. Hartinger

Dalton Trans., 2016, 45, 13091
DOI: 10.1039/C6DT01110A

Visible-light-promoted iron-catalyzed C–H functionalization of 1,4-naphthoquinones via oxidative coupling with sulfoximines

Alpa Sharma, Harpreet Kour, Jaspreet Kour, Kamal and Sanghapal D. Sawant

Chem. Commun., 2022, 58, 11312
DOI: 10.1039/D2CC03319D

Exploiting photooxygenations mediated by porphyrinoid photocatalysts under continuous flow conditions

Kleber T. de Oliveira, L. Zane Miller and D. Tyler McQuade

RSC Adv., 2016, 6, 12717
DOI: 10.1039/C6RA00285D

Design, synthesis and biological evaluation of naphthalene-1,4-dione analogues as anticancer agents

Yao Cheng, Tsz Tin Yu, Ellen M. Olzomer, Martina Beretta, Alice Katen, Jacky Su, John Patrick Jones, David StC Black, Kyle L. Hoehn, Frances L. Byrne and Naresh Kumar

RSC Med. Chem., 2025, 16, 2677
DOI: 10.1039/D4MD00987H

In vitro anticancer evaluation of Enceleamycin A and its underlying mechanism

Abujunaid Khan, S. Pradeep and Syed G. Dastager

RSC Adv., 2023, 13, 34183
DOI: 10.1039/D3RA06204J

Transition metal-free cyclobutene rearrangement in fused naphthalen-1-ones: controlled access to functionalized quinones

Fernando Herrera, Amparo Luna, Israel Fernández and Pedro Almendros

Chem. Commun., 2020, 56, 1290
DOI: 10.1039/C9CC08628E

Catalytic asymmetric reactions and synthesis of quinones

Basavaprabhu Hosamani, Matheus F. Ribeiro, Eufrânio N. da Silva Júnior and Irishi N. N. Namboothiri

Org. Biomol. Chem., 2016, 14, 6913
DOI: 10.1039/C6OB01119E

Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation

Amaç F. Tuyun, Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Emel Mataracı Kara, Ayse T. Jannuzzi and Berna Ozbek Celik

Drug Development Research, 2019, 80, 1098
DOI: 10.1002/ddr.21591

Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction

Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Betul Karademir Yilmaz, Deepak Shilkar, Raghusrinivasan Jayaprakash Venkatesan, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Pharmaceuticals, 2022, 15, 777
DOI: 10.3390/ph15070777

Synthesis, Molecular Docking, Some Metabolic Enzyme Inhibition Properties, and Antioxidant Activity Studies of 1,4-Naphthoquinones

Onur Ertik, Nihal Onul, Kamala Asgarova and Refiye Yanardag

Russ J Bioorg Chem, 2024, 50, 1001
DOI: 10.1134/S1068162024030269

Redox Center Modification of Lapachones towards the Synthesis of Nitrogen Heterocycles as Selective Fluorescent Mitochondrial Imaging Probes

Fabíola S. dos Santos, Gleiston G. Dias, Rossimiriam P. de Freitas, Lucas S. Santos, Guilherme F. de Lima, Hélio A. Duarte, Carlos A. de Simone, Lidia M. S. L. Rezende, Monique J. X. Vianna, José R. Correa, Brenno A. D. Neto and Eufrânio N. da Silva Júnior

Eur J Org Chem, 2017, 2017, 3763
DOI: 10.1002/ejoc.201700227

A promising naphthoquinone [8-hydroxy-2-(2-thienylcarbonyl)naphtho[2,3-b]thiophene-4,9-dione] exerts anti-colorectal cancer activity through ferroptosis and inhibition of MAPK signaling pathway based on RNA sequencing

Daneiva Caro, David Rivera, Yanet Ocampo, Klaus Müller and Luis A. Franco

Open Chemistry, 2020, 18, 1242
DOI: 10.1515/chem-2020-0170

Antibacterial and Cytotoxic Compounds from Endophyte Fusarium solani isolated from Centella asiatica (L.)

Fatema Moni, Naki Saifullah, Farhana Afroz, Satyajit Roy Rony, Suriya Sharmin, ADA Shahinuzzaman, Muhammad Abdullah Al-Mansur, Sharif Md. Al-Reza and Md. Hossain Sohrab

Journal of Biologically Active Products from Nature, 2022, 12, 436
DOI: 10.1080/22311866.2022.2144947

Proapoptotic Effects of triazol-1,4-Naphthoquinones Involve Intracellular ROS Production and MAPK/ERK Pathway in Human Leukemia Cells

Tangbadioa H. Coulidiati, Bruna B. Dantas, Glaucia V. Faheina-Martins, Enéas Ricardo de Morais Gomes, Juan C.R. Gonçalves and Demetrius A. Machado de Araújo

ACAMC, 2020, 20, 2089
DOI: 10.2174/1871520620666200721124221

Synthesis of Quinone‐Based N‐Sulfonyl‐1,2,3‐triazoles: Chemical Reactivity of Rh(II) Azavinyl Carbenes and Antitumor Activity

Wagner O. Valença, Thekke V. Baiju, Fernanda G. Brito, Maria H. Araujo, Claudia Pessoa, Bruno C. Cavalcanti, Carlos A. de Simone, Claus Jacob, Irishi N. N. Namboothiri and Eufrânio N. da Silva Júnior

ChemistrySelect, 2017, 2, 4301
DOI: 10.1002/slct.201700885

Current status of 1,4-Naphthoquinones and their derivatives for wound healing

Pooja Kumari, Vikramjeet Singh, Vinay Kant and Munish Ahuja

European Journal of Medicinal Chemistry Reports, 2024, 12, 100194
DOI: 10.1016/j.ejmcr.2024.100194

Naphtho[1′,2′:4,5]imidazo[1,2-a]pyridine-5,6-diones: Synthesis, enzymatic reduction and cytotoxic activity

Jonas Šarlauskas, Milda Pečiukaitytė-Alksnė, Lina Misevičienė, Audronė Marozienė, Evelina Polmickaitė, Zita Staniulytė, Narimantas Čėnas and Žilvinas Anusevičius

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 512
DOI: 10.1016/j.bmcl.2015.11.084

Genotoxicity of quinone: An insight on DNA adducts and its LC-MS-based detection

Yue Xiong, Han Yeong Kaw, Lizhong Zhu and Wei Wang

Critical Reviews in Environmental Science and Technology, 2022, 52, 4217
DOI: 10.1080/10643389.2021.2001276

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents

Han‐Yue Qiu, Peng‐Fei Wang, Hong‐Yan Lin, Cheng‐Yi Tang, Hai‐Liang Zhu and Yong‐Hua Yang

Chem Biol Drug Des, 2018, 91, 681
DOI: 10.1111/cbdd.13141

Polymorphism in chloro derivatives of 1,4-naphthoquinone: Experiment and density functional theoretic investigations

Dinkar Chaudhari, Shridhar P. Gejji, Dipali N. Lande, Debamitra Chakravarty and Sunita Salunke-Gawali

Journal of Molecular Structure, 2016, 1120, 281
DOI: 10.1016/j.molstruc.2016.05.022

Novel plastoquinone analogs containing benzocaine and its analogs: structure‐based design, synthesis, and structural characterization

Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Emel Mataracı-Kara and Amaç Fatih Tuyun

Res Chem Intermed, 2021, 47, 2125
DOI: 10.1007/s11164-020-04384-5

Vibrational, spectroscopic, chemical reactivity, molecular docking and in vitro anticancer activity studies against A549 lung cancer cell lines of 5‐Bromo‐indole‐3‐carboxaldehyde

Christopher Jeyaseelan S., Milton Franklin Benial A. and Kaviyarasu K.

J of Molecular Recognition, 2021, 34
DOI: 10.1002/jmr.2873

Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative

Kun Li, Baitao Wang, Lifang Zheng, Kun Yang, Yuanyuan Li, Minmin Hu and Dian He

Bioorganic & Medicinal Chemistry Letters, 2018, 28, 273
DOI: 10.1016/j.bmcl.2017.12.059

A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone

Lakshmi Swarna Mukhi Pidugu, J.C. Emmanuel Mbimba, Muqeet Ahmad, Edwin Pozharski, Edward A. Sausville, Ashkan Emadi and Eric A. Toth

BMC Struct Biol, 2016, 16
DOI: 10.1186/s12900-016-0052-x

A LAT1‐Compatible, Leadlike Tyrosine‐Naphthoquinone Conjugate With Anticancer Activity

Austin Seymour, Christian Peterson, Raymond Osafo, Abdullahi A. Ashimi, Dylan Williams, Laura Echezabal, Chelsea Carrier, Alysa Clarke, Clifford W. Padgett, Mark Vincent C. dela Cerna, Zheni Utic, Divine Wanduku, Nathaniel Shank, Karelle S. Aiken and Jannet Kocerha

Drug Development Research, 2026, 87
DOI: 10.1002/ddr.70269

Novel lawsone-containing ruthenium(II) complexes: Synthesis, characterization and anticancer activity on 2D and 3D spheroid models of prostate cancer cells

Rone Aparecido De Grandis, Patrick Wellington da Silva dos Santos, Katia Mara de Oliveira, Ana Rita Tomazela Machado, Alexandre Ferro Aissa, Alzir Azevedo Batista, Lusânia Maria Greggi Antunes and Fernando Rogério Pavan

Bioorganic Chemistry, 2019, 85, 455
DOI: 10.1016/j.bioorg.2019.02.010

Click chemistry-assisted synthesis of novel aminonaphthoquinone-1,2,3-triazole hybrids and investigation of their cytotoxicity and cancer cell cycle alterations

Maryam Gholampour, Sara Ranjbar, Najmeh Edraki, Maryam Mohabbati, Omidreza Firuzi and Mehdi Khoshneviszadeh

Bioorganic Chemistry, 2019, 88, 102967
DOI: 10.1016/j.bioorg.2019.102967

Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones

Juana Andrea Ibacache, Jaime A. Valderrama, Judith Faúndes, Alex Danimann, Francisco J. Recio and César A. Zúñiga

Molecules, 2019, 24, 4378
DOI: 10.3390/molecules24234378

Prisconnatanones A, a cytotoxic naphthoquinone from Prismatomeris connata, suppresses the proliferation of human laryngocarcinoma HEp-2 cells in vitro

Shixiu Feng, Min Zhang, Jing Xu and Yinming Hu

Natural Product Research, 2016, 30, 2840
DOI: 10.1080/14786419.2016.1160234

Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and their mechanistic insights

Eduardo H.G. da Cruz, Molly A. Silvers, Guilherme A.M. Jardim, Jarbas M. Resende, Bruno C. Cavalcanti, Igor S. Bomfim, Claudia Pessoa, Carlos A. de Simone, Giancarlo V. Botteselle, Antonio L. Braga, Divya K. Nair, Irishi N.N. Namboothiri, David A. Boothman and Eufrânio N. da Silva Júnior

European Journal of Medicinal Chemistry, 2016, 122, 1
DOI: 10.1016/j.ejmech.2016.06.019

TEMPO-Mediated Direct C(sp2)–H Alkoxylation/Aryloxylation of 1,4-Quinones

Amol B. Gadekar, Dhananjay S. Nipate, Krishnan Rangan and Anil Kumar

J. Org. Chem., 2025, 90, 1044
DOI: 10.1021/acs.joc.4c02335

Design and synthesis of new 1,4-naphthoquinones appended sulfenylated thiazoles as cyclooxygenase II inhibitors: Exploring the utility in the development of anticancer agents

Priyanka, Payal Rani, Anju Ranolia, Kiran, Gaurav Joshi, Snigdha Singh, Roshan Kumar, Muhammad Wahajuddin, Parvin Kumar, Devender Singh and Jayant Sindhu

Bioorganic Chemistry, 2025, 161, 108537
DOI: 10.1016/j.bioorg.2025.108537

Studies on Cytotoxic Activity against HepG-2 Cells of Naphthoquinones from Green Walnut Husks of Juglans mandshurica Maxim

Yuanyuan Zhou, Bingyou Yang, Yanqiu Jiang, Zhaoxi Liu, Yuxin Liu, Xiaoli Wang and Haixue Kuang

Molecules, 2015, 20, 15572
DOI: 10.3390/molecules200915572

Isolation and Structure Elucidation of Compounds from Sesamum alatum and Their Antiproliferative Activity against Multiple Myeloma Cells

Noémie Saraux, Sylvian Cretton, Ozlem Sevik Kilicaslan, Coralie Occioni, Angelica Ferro, Luis Quirós-Guerrero, Soumana Karimou, Philippe Christen and Muriel Cuendet

J. Nat. Prod., 2022, 85, 2706
DOI: 10.1021/acs.jnatprod.2c00406

Anticancer agents based on Plastoquinone analogs with N-phenylpiperazine: Structure-activity relationship and mechanism of action in breast cancer cells

Ayse Tarbin Jannuzzi, Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Chemico-Biological Interactions, 2021, 349, 109673
DOI: 10.1016/j.cbi.2021.109673

Cytotoxicity and reactivity of a redox active 1,4-quinone-pyrazole compound and its Ru(II)-p-cymene complex

Kallol Purkait and Arindam Mukherjee

Inorganica Chimica Acta, 2020, 502, 119361
DOI: 10.1016/j.ica.2019.119361

Direct Functionalization of para‐Quinones: A Historical Review and New Perspectives

Raushan Kumar Jha and Sangit Kumar

Eur J Org Chem, 2024, 27
DOI: 10.1002/ejoc.202400535

Synthesis of a Thioglucoside and Its Tetracyclic Conjugate Based on 6-Bromo-1,4-naphthoquinone Derivatives

S. G. Polonik, R. S. Popov, V. V. Makhankov and Yu. E. Sabutski

Russ J Org Chem, 2023, 59, 573
DOI: 10.1134/S1070428023040036

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress

Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar and Kyle L. Hoehn

Redox Biology, 2020, 28, 101374
DOI: 10.1016/j.redox.2019.101374

Advancement and recent trends in seeking less toxic and more active anti-cancer drugs: Insights into thiourea based molecules

Walaa Alharbi

Main Group Chemistry, 2022, 21, 885
DOI: 10.3233/MGC-210183

Naphthoquinone Derivatives Targeting Melanoma

Jéssica Alves Nunes, Adrielle Firmino da Silva Nunes, Dimas José da Paz Lima and Edeildo Ferreira da Silva-Júnior

CTMC, 2023, 23, 2863
DOI: 10.2174/1568026623666230901124059

Advancing one-pot green synthesis of plant-derived nanomaterials for extraction techniques, characterization, multifunctional biomedical applications, challenges and future perspectives

Naveen Palani, Keren Celestina Mendonce, Rabiya Riffath Syed Altaf, Agilandeswari Mohan, Parthasarathy Surya, Monisha P. and Suriyaprakash Rajadesingu

Materials Today Communications, 2025, 46, 112780
DOI: 10.1016/j.mtcomm.2025.112780

Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling

Panupong Mahalapbutr, Ronnakorn Leechaisit, Anusit Thongnum, Duangjai Todsaporn, Veda Prachayasittikul, Thanyada Rungrotmongkol, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul and Ratchanok Pingaew

ACS Omega, 2022, 7, 17881
DOI: 10.1021/acsomega.2c01188

Anti-acute myeloid leukemia activity of 2-chloro-3-alkyl-1,4-naphthoquinone derivatives through inducing mtDNA damage and GSH depletion

Kun Li, Kun Yang, Lifang Zheng, Yuanyuan Li, Qi Wang, Ruili Lin and Dian He

Bioorganic & Medicinal Chemistry, 2018, 26, 4191
DOI: 10.1016/j.bmc.2018.07.010

Evaluation of Cytotoxic Effect of Onosma armeniacum Extract on Various Cancer Cells

Selim DEMİR, Elif AYAZOGLU DEMİR, İbrahim TURAN and Ufuk ÖZGEN

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 2021, 24, 252
DOI: 10.18016/ksutarimdoga.vi.729814

Antimicrobial and wound healing potential of naphthoquinones encapsulated in nanochitosan

Cyntia Silva Freitas, Patricia Ribeiro Pereira, Raiane Vieira Cardoso, Fernanda Petzold Pauli, Ruan Carlos Busquet Ribeiro, Fernando De Carvalho Da Silva, Vitor Francisco Ferreira and Vania Margaret Flosi Paschoalin

Front. Bioeng. Biotechnol., 2024, 11
DOI: 10.3389/fbioe.2023.1284630

Podophyllotoxin derivatives as an excellent anticancer aspirant for future chemotherapy: A key current imminent needs

Xu Zhang, K.P. Rakesh, C.S. Shantharam, H.M. Manukumar, A.M. Asiri, H.M. Marwani and Hua-Li Qin

Bioorganic & Medicinal Chemistry, 2018, 26, 340
DOI: 10.1016/j.bmc.2017.11.026

Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer

Sergey A. Dyshlovoy, Dmitry N. Pelageev, Jessica Hauschild, Yurii E. Sabutskii, Ekaterina A. Khmelevskaya, Christoph Krisp, Moritz Kaune, Simone Venz, Ksenia L. Borisova, Tobias Busenbender, Vladimir A. Denisenko, Hartmut Schlüter, Carsten Bokemeyer, Markus Graefen, Sergey G. Polonik, Victor Ph. Anufriev and Gunhild von Amsberg

Marine Drugs, 2020, 18, 251
DOI: 10.3390/md18050251

Scaffold Hopping and Structural Modification of NSC 663284: Discovery of Potent (Non)Halogenated Aminobenzoquinones

Nilüfer Bayrak, Belgin Sever, Halilibrahim Ciftci, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Biomedicines, 2023, 12, 50
DOI: 10.3390/biomedicines12010050

1,4-Naphthoquinone Analogues: Potent Antibacterial Agents and Mode of Action Evaluation

Palanisamy Ravichandiran, Sunirmal Sheet, Dhanraj Premnath, Ae Rhan Kim and Dong Jin Yoo

Molecules, 2019, 24, 1437
DOI: 10.3390/molecules24071437

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

Reece G. Kenny and Celine J. Marmion

Chem. Rev., 2019, 119, 1058
DOI: 10.1021/acs.chemrev.8b00271

Natural products and their derivatives as anti-flavivirus drug candidates

Carolina Sousa Ponciano, Eloah Pereira Ávila, Richard Michael Grazul, Larissa Albuquerque de Oliveira Mendes and Mauro Vieira de Almeida

Med Chem Res, 2021, 30, 1056
DOI: 10.1007/s00044-021-02718-5

Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-ActivityAnalysis of Substituted 5,8-Dihydroxy-1,4-naphthoquinones and Their O- and S-Glycoside Derivatives Tested against Neuro-2a Cancer Cells

Sergey Polonik, Galina Likhatskaya, Yuri Sabutski, Dmitry Pelageev, Vladimir Denisenko, Evgeny Pislyagin, Ekaterina Chingizova, Ekaterina Menchinskaya and Dmitry Aminin

Marine Drugs, 2020, 18, 602
DOI: 10.3390/md18120602

Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations

János P. Mészáros, Heiko Geisler, Jelena M. Poljarević, Alexander Roller, Maria S. Legina, Michaela Hejl, Michael A. Jakupec, Bernhard K. Keppler, Wolfgang Kandioller and Éva A. Enyedy

Journal of Organometallic Chemistry, 2020, 907, 121070
DOI: 10.1016/j.jorganchem.2019.121070

Synthesis and Cytotoxicity Studies of Stilbene Long-Chain Fatty Acid Conjugates

Thomas Wong, Silpa Narayanan, David P. Brown and Zhe-Sheng Chen

J. Nat. Prod., 2020, 83, 1563
DOI: 10.1021/acs.jnatprod.0c00027

Thiol Reactivity of Curcumin and Its Oxidation Products

Paula B. Luis, William E. Boeglin and Claus Schneider

Chem. Res. Toxicol., 2018, 31, 269
DOI: 10.1021/acs.chemrestox.7b00326

Exploring the Antibacterial and Antiparasitic Activity of Phenylaminonaphthoquinones—Green Synthesis, Biological Evaluation and Computational Study

Sussan Lopez-Mercado, Cinthya Enríquez, Jaime A. Valderrama, Ricardo Pino-Rios, Liliana Ruiz-Vásquez, Lastenia Ruiz Mesia, Gabriel Vargas-Arana, Pedro Buc Calderon and Julio Benites

IJMS, 2024, 25, 10670
DOI: 10.3390/ijms251910670

Spectroscopic and in silico characterization of the interaction between synthetic 2-substituted-naphtho-1,4-quinones and human serum albumin

Micaeli Louise da Silva Moreira, Otávio Augusto Chaves, Nanci Camara de Lucas, Juliana da Silva Goulart, Simon J. Garden, Carlos Serpa and José Carlos Netto-Ferreira

Journal of Molecular Liquids, 2024, 403, 124829
DOI: 10.1016/j.molliq.2024.124829

Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells

Dora C.S. Costa, Gabriella Silva de Almeida, Vitor Won-Held Rabelo, Lucio Mendes Cabral, Plínio Cunha Sathler, Paula Alvarez Abreu, Vitor Francisco Ferreira, Luiz Cláudio Rodrigues Pereira da Silva and Fernando de C. da Silva

European Journal of Medicinal Chemistry, 2018, 156, 524
DOI: 10.1016/j.ejmech.2018.07.018

Identification and Characterization of Natural and Semisynthetic Quinones as Aurora Kinase Inhibitors

Muhammad Furqan, Alishba Fayyaz, Farhat Firdous, Hadeeqa Raza, Aishah Bilal, Rahman Shah Zaib Saleem, Syed Shahzad-ul-Hussan, Daijie Wang, Fadia S. Youssef, Nawal M. Al Musayeib, Mohamed L. Ashour, Hidayat Hussain and Amir Faisal

J. Nat. Prod., 2022, 85, 1503
DOI: 10.1021/acs.jnatprod.1c01222

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

William D.J. Tremlett, David M. Goodman, Tasha R. Steel, Saawan Kumar, Anna Wieczorek-Błauż, Fearghal P. Walsh, Matthew P. Sullivan, Muhammad Hanif and Christian G. Hartinger

Coordination Chemistry Reviews, 2021, 445, 213950
DOI: 10.1016/j.ccr.2021.213950

Antitumoral activity of novel 1,4-naphthoquinone derivative involves L-type calcium channel activation in human colorectal cancer cell line

Juan Carlos Ramos Gonçalves, Tangbadioa Herve Coulidiati, André Luís Monteiro, Laís Campos Teixeira de Carvalho-Gonçalves, Wagner de Oliveira Valença, Ronaldo Nascimento de Oliveira, Celso de Amorim Câmara and Demetrius Antônio Machado de Araújo

J Appl Biomed, 2016, 14, 229
DOI: 10.1016/j.jab.2016.03.002

A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways

Patricia D.O. de Almeida, Gleyce dos Santos Barbosa Jobim, Caio César dos Santos Ferreira, Lucas Rocha Bernardes, Rosane B. Dias, Caroline B. Schlaepfer Sales, Ludmila de F. Valverde, Clarissa A.G. Rocha, Milena B.P. Soares, Daniel P. Bezerra, Fernando de Carvalho da Silva, Mariana Filomena do Carmo Cardoso, Vitor Francisco Ferreira, Larissa F. Brito, Lirlândia Pires de Sousa, Marne C. de Vasconcellos and Emerson S. Lima

Chemico-Biological Interactions, 2021, 343, 109444
DOI: 10.1016/j.cbi.2021.109444

Treasures from the forest: Evaluation of mushroom extracts as anti-cancer agents

Patryk Nowakowski, Renata Markiewicz-Żukowska, Joanna Bielecka, Konrad Mielcarek, Monika Grabia and Katarzyna Socha

Biomedicine & Pharmacotherapy, 2021, 143, 112106
DOI: 10.1016/j.biopha.2021.112106

In silico investigations of natural-product tethered 1,4-naphthoquinones as inhibitors of Staphylococcus aureus

Satyam Srivastava, Harish C. Upadhyay and Dharmendra K. Yadav

Biochemical and Biophysical Research Communications, 2025, 778, 152333
DOI: 10.1016/j.bbrc.2025.152333

Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

Jinlei Bian, Tinghan Li, Tianwei Weng, Jubo Wang, Yu Chen and Zhiyu Li

Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1012
DOI: 10.1016/j.bmcl.2016.12.076

A novel naphthoquinone derivative shows selective antifungal activity against Sporothrix yeasts and biofilms

Luana P. Borba-Santos, Caroline Deckmann Nicoletti, Taissa Vila, Patricia Garcia Ferreira, Carlos Fernando Araújo-Lima, Bárbara Verena Dias Galvão, Israel Felzenszwalb, Wanderley de Souza, Fernando de Carvalho da Silva, Vitor Francisco Ferreira, Debora Omena Futuro and Sonia Rozental

Braz J Microbiol, 2022, 53, 749
DOI: 10.1007/s42770-022-00725-1

Naphthoquinone Derivatives Isolated from Plants: Recent Advances in Biological Activity

Esmaeil Sheikh Ahmadi, Amir Tajbakhsh, Milad Iranshahy, Javad Asili, Nadine Kretschmer, Abolfazl Shakeri and Amirhossein Sahebkar

MRMC, 2020, 20, 2019
DOI: 10.2174/1389557520666200818212020

Chemoselective one-pot access to benzo[e]indole-4,5-diones and naphtho[2,1-b]thiophene-4,5-diones via copper-catalyzed oxidative [3 + 2] annulation of α-oxoketene N,S-acetals/β-ketothioamides with α-/β-naphthols

Dhananjay Yadav, Gaurav Shukla, Monish A. Ansari, Abhijeet Srivastava and Maya Shankar Singh

Tetrahedron, 2018, 74, 5920
DOI: 10.1016/j.tet.2018.08.026

Blue Light Irradiated Metal-, Oxidant-, and Base-Free Cross-Dehydrogenative Coupling of C(sp2)–H and N–H Bonds: Amination of Naphthoquinones with Amines

Raushan Kumar Jha, Monojit Batabyal and Sangit Kumar

J. Org. Chem., 2023, 88, 7401
DOI: 10.1021/acs.joc.3c00666

Thiolated plastoquinone analogs: Synthesis, characterization, and antimicrobial evaluation

Hatice Yıldırım, Nilüfer Bayrak, Mahmut Yıldız, Emel Mataracı Kara, Berna Ozbek Celik and Amaç Fatih Tuyun

Journal of Molecular Structure, 2019, 1195, 681
DOI: 10.1016/j.molstruc.2019.05.076

Design, synthesis, characterization, and antimicrobial activity of novel piperazine substituted 1,4-benzoquinones

Mahmut Yıldız

Journal of Molecular Structure, 2020, 1203, 127422
DOI: 10.1016/j.molstruc.2019.127422

Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate‐Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli

Isam Elamri, Melanie Radloff, Katharina F. Hohmann, Vijaykumar D. Nimbarte, Hamid R. Nasiri, Michael Bolte, Schara Safarian, Hartmut Michel and Harald Schwalbe

ChemMedChem, 2020, 15, 1262
DOI: 10.1002/cmdc.201900707

Biomimetic synthesis and anticancer activity of Eurycoma longifolia branch extract‐mediated silver nanoparticles

Devi Nallappan, Prasad N.V.K.V Tollamadugu, Agustine Nengsih Fauzi, Nik Soriani Yaacob and Visweswara Rao Pasupuleti

IET Nanobiotechnology, 2017, 11, 889
DOI: 10.1049/iet-nbt.2016.0181

Novel naphthoquinones as potent aromatase inhibitors: Synthesis, anticancer, and in silico studies

Ronnakorn Leechaisit, Panupong Mahalapbutr, Utid Suriya, Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul and Ratchanok Pingaew

Journal of Molecular Structure, 2024, 1316, 138981
DOI: 10.1016/j.molstruc.2024.138981

A study on bond length compression effect of lone pair electrons in polycyclic heterocyclic quinones

Chun Lei, Jiefeng Lin, Jiaohong Xu, Yongfan Zhang, Yaofeng Yuan, Bin Wang, Wenfeng Wang and Yongguo Liu

Computational and Theoretical Chemistry, 2026, 1255, 115566
DOI: 10.1016/j.comptc.2025.115566

Reactive Oxygen Species Release, Alkylating Ability, and DNA Interactions of a Pterocarpanquinone: A Test Case for Electrochemistry

Thaissa L. Silva, Fabricia R. Ferreira, Camila C. de Vasconcelos, Rosanny Christhinny da Silva, Dimas José da P. Lima, Paulo R. R. Costa, Chaquip D. Netto and Marília O. F. Goulart

ChemElectroChem, 2016, 3, 2252
DOI: 10.1002/celc.201600504

All that glitters is not gold: Panning cytotoxic natural products and derivatives with a fused tricyclic backbone by the estimation of their leadlikeness for cancer treatment

Luiz Carlos Klein-Júnior, Rogério Corrêa, Yvan Vander Heyden and Valdir Cechinel Filho

European Journal of Medicinal Chemistry, 2019, 166, 1
DOI: 10.1016/j.ejmech.2019.01.028

Fungal Pigments: Potential Coloring Compounds for Wide Ranging Applications in Textile Dyeing

Chidambaram Kulandaisamy Venil, Palanivel Velmurugan, Laurent Dufossé, Ponnuswamy Renuka Devi and Arumugam Veera Ravi

JoF, 2020, 6, 68
DOI: 10.3390/jof6020068

Chemoselective Synthesis of Mannich Adducts from 1,4-Naphthoquinones and Profile as Autophagic Inducers in Oral Squamous Cell Carcinoma

Amanda A. Borges, Michele P. de Souza, Anna Carolina C. da Fonseca, Guilherme F. Wermelinger, Ruan C. B. Ribeiro, Adriane A. P. Amaral, Cláudio José C. de Carvalho, Lucas S. Abreu, Lucas Nicolau de Queiroz, Elan C. P. de Almeida, Vitor W. Rabelo, Paula A. Abreu, Bruno Pontes, Vitor F. Ferreira, Fernando de C. da Silva, Luana da S. M. Forezi and Bruno K. Robbs

Molecules, 2022, 28, 309
DOI: 10.3390/molecules28010309

Triphenylantimony(V) Catecholates of the Type (3-RS-4,6-DBCat)SbPh3-Catechol Thioether Derivatives: Structure, Electrochemical Properties, and Antiradical Activity

Ivan V. Smolyaninov, Georgy K. Fukin, Nadezhda T. Berberova and Andrey I. Poddel’sky

Molecules, 2021, 26, 2171
DOI: 10.3390/molecules26082171

Copper(I)/Triphenylphosphine Complexes Containing Naphthoquinone Ligands as Potential Anticancer Agents

Celisnolia M. Leite, João H. Araujo-Neto, Adriana P. M. Guedes, Analu R. Costa, Felipe C. Demidoff, Chaquip D. Netto, Eduardo E. Castellano, Otaciro R. Nascimento and Alzir A. Batista

Inorganics, 2023, 11, 367
DOI: 10.3390/inorganics11090367

Catalytic application of a nano-molten salt catalyst in the synthesis of biological naphthoquinone-based compounds

Meysam Yarie, Mohammad Ali Zolfigol, Saeed Babaee, Saeed Baghery, Diego A. Alonso and Abbas Khoshnood

Res Chem Intermed, 2018, 44, 2839
DOI: 10.1007/s11164-018-3264-9

Design, Synthesis and Cytotoxicity of Thiazole-Based Stilbene Analogs as Novel DNA Topoisomerase IB Inhibitors

Jin-Chuan Liu, Bo Chen, Jia-Lin Yang, Jian-Quan Weng, Qian Yu and De-Xuan Hu

Molecules, 2022, 27, 1009
DOI: 10.3390/molecules27031009

On the Influence of the Terpene Fragment on the Reaction of 1,3-Dipolaric Cycloaddition of Diazoketons to 1,4-Benzoquinone

R. M. Sultanova, V. K. Yangubaeva, K. A. Valiullina and R. N. Malikova

BCJ, 2018, 25, 3
DOI: 10.17122/bcj-2018-3-3-9

Rapid, Operationally Simple, and Metal‐free NBS Mediated One‐pot Synthesis of 1,2‐Naphthoquinone from 2‐Naphthol

Jaeuk Sim, Hyeju Jo, Mayavan Viji, Minho Choi, Jin‐Ah Jung, Heesoon Lee and Jae‐Kyung Jung

Adv Synth Catal, 2018, 360, 852
DOI: 10.1002/adsc.201701312

Metal Complexes of Natural Product Like-compounds with Antitumor Activity

Beatriz L. Heras, Ángel Amesty, Ana Estévez-Braun and Sonsoles Hortelano

ACAMC, 2019, 19, 48
DOI: 10.2174/1871520618666180420165821

Quambalarine B, a Secondary Metabolite fromQuambalaria cyanescenswith Potential Anticancer Properties

Valéria Grobárová, Karel Vališ, Pavel Talacko, Barbora Pavlů, Lucie Hernychová, Jana Nováková, Eva Stodůlková, Miroslav Flieger, Petr Novák and Jan Černý

J. Nat. Prod., 2016, 79, 2304
DOI: 10.1021/acs.jnatprod.6b00362

Electrochemical transformations and anti/prooxidant activity of sterically hindered o-benzoquinones

I. V. Smolyaninov, V. V. Kuzmin, M. V. Arsenyev, S. A. Smolyaninova, A. I. Poddel´sky and N. T. Berberova

Russ Chem Bull, 2017, 66, 1217
DOI: 10.1007/s11172-017-1876-7

Synthesis of Novel Mannich Derivatives of Bakuchiol as Apoptotic Inducer through Caspase Activation and PARP‐1 Cleavage in A549 Cells

Nidhi Gupta, Sonia Sharma, Arun Raina, Shashi Bhushan, Fayaz A. Malik and Payare L. Sangwan

ChemistrySelect, 2017, 2, 5196
DOI: 10.1002/slct.201700504

1H and 13C NMR chemical shifts of 2-n-alkylamino-naphthalene-1,4-diones

Rishikesh Patil, Mahesh Jadhav, Sunita Salunke-Gawali, Dipali N. Lande, Shridhar P. Gejji and Debamitra Chakravarty

Heliyon, 2021, 7, e06044
DOI: 10.1016/j.heliyon.2021.e06044

Quality parameters for the medicinal plant Drosera rotundifolia L.: A new approach with established techniques

Sandy Gerschler, Niclas Neumann, Nadin Schultze, Sebastian Guenther and Christian Schulze

Archiv der Pharmazie, 2024, 357
DOI: 10.1002/ardp.202300436

Antitumoral effect of novel synthetic 8-hydroxy-2-((4-nitrophenyl)thio)naphthalene-1,4-dione (CNN16) via ROS-mediated DNA damage, apoptosis and anti-migratory effect in colon cancer cell line

Emerson Lucena da Silva, Felipe Pantoja Mesquita, Ingryd Nayara de Farias Ramos, Carinne Borges de Souza Moraes Rego Gomes, Caroline dos Santos Moreira, Vítor Francisco Ferreira, David Rodrigues da Rocha, Marcelo de Oliveira Bahia, Caroline Aquino Moreira-Nunes, Carolina Rosal Teixeira de Souza, Rommel Mario Rodrigues Burbano and Raquel Carvalho Montenegro

Toxicology and Applied Pharmacology, 2022, 456, 116256
DOI: 10.1016/j.taap.2022.116256

Experimental and theoretical investigations of novel oxidovanadium(IV) juglone complex: DNA/HSA interaction and cytotoxic activity

Fatemeh Abyar and Leila Tabrizi

Journal of Biomolecular Structure and Dynamics, 2020, 38, 474
DOI: 10.1080/07391102.2019.1580221

8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties

Cathrin Lindenschmidt, Dirk Krane, Silke Vortherms, Lars Hilbig, Helge Prinz and Klaus Müller

European Journal of Medicinal Chemistry, 2016, 110, 280
DOI: 10.1016/j.ejmech.2016.01.040

The Antifungal Activity of Naphthoquinones: An Integrative Review

DÉBORA O. FUTURO, PATRICIA G. FERREIRA, CAROLINE D. NICOLETTI, LUANA P. BORBA-SANTOS, FERNANDO C. DA SILVA, SONIA ROZENTAL and VITOR FRANCISCO FERREIRA

An. Acad. Bras. Ciênc., 2018, 90, 1187
DOI: 10.1590/0001-3765201820170815

1,4-Naphthoquinones: Some Biological Properties and Application

Dmitry Aminin and Sergey Polonik

Chem. Pharm. Bull., 2020, 68, 46
DOI: 10.1248/cpb.c19-00911

Anti-melanoma effect of ruthenium(II)-diphosphine complexes containing naphthoquinone ligand

Francisco Rinaldi-Neto, Arthur Barcelos Ribeiro, Natália Helen Ferreira, Iara Silva Squarisi, Kátia Mara Oliveira, Renato Pereira Orenha, Renato Luís Tame Parreira, Alzir Azevedo Batista and Denise Crispim Tavares

Journal of Inorganic Biochemistry, 2021, 222, 111497
DOI: 10.1016/j.jinorgbio.2021.111497

Aromatase (CYP19) inhibition by biflavonoids obtained from the branches of Garcinia gardneriana (Clusiaceae)

Angelica Maria Recalde-Gil, Luiz Klein-Júnior, Juliana Salton, Sérgio Bordignon, Valdir Cechinel-Filho, Cristiane Matté and Amélia Henriques

Zeitschrift für Naturforschung C, 2019, 74, 279
DOI: 10.1515/znc-2019-0036

Exploration of naphthoquinone analogs in targeting the TCF-DNA interaction to inhibit the Wnt/β-catenin signaling pathway

Andrew Morris, Rosalie Hoyle, Piyusha P. Pagare, Shadid Uz Zaman, Zhikun Ma, Jiong Li and Yan Zhang

Bioorganic Chemistry, 2022, 124, 105812
DOI: 10.1016/j.bioorg.2022.105812

The synthesis of thioglucoside and their tetracyclic conjugate based on 6-bromo-1,4-naphthoquinone

S. G Polonik, R. S Popov, V. V Makhankov and Y. E Sabutskii

Žurnal organičeskoj himii, 2023, 59, 444
DOI: 10.31857/S0514749223040031

Design, Synthesis, and Antibacterial Activities of Multi‐Functional C2‐Functionalized 1,4‐Naphthoquinonyl Organoseleniums

Raushan Kumar Jha, Chhavi, Svastik Jaiswal, Devendra Parganiha, Vishal Choudhary, Deepanshi Saxena, Rahul Maitra, Swechcha Singh, Sidharth Chopra and Sangit Kumar

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202401054

2-Phenoxy-1,4-naphthoquinones: From a Multitarget Antitrypanosomal to a Potential Antitumor Profile

Federica Prati, Christian Bergamini, Maria Teresa Molina, Federico Falchi, Andrea Cavalli, Marcel Kaiser, Reto Brun, Romana Fato and Maria Laura Bolognesi

J. Med. Chem., 2015, 58, 6422
DOI: 10.1021/acs.jmedchem.5b00748

Synthesis of quinone-based heterocycles of broad-spectrum anticancer activity

Ashraf A Aly, Alaa A Hassan, Nasr K Mohamed, Mohamed Ramadan, Amal S Abd El-Aal, Stefan Bräse and Martin Nieger

Journal of Chemical Research, 2021, 45, 562
DOI: 10.1177/1747519820959737

Tautomerism in o-hydroxyanilino-1,4-naphthoquinone derivatives: Structure, NMR, HPLC and density functional theoretic investigations

Sujit Bhand, Rishikesh Patil, Yogesh Shinde, Dipali N. Lande, Soniya S. Rao, Laxmi Kathawate, Shridhar P. Gejji, Thomas Weyhermüller and Sunita Salunke-Gawali

Journal of Molecular Structure, 2016, 1123, 245
DOI: 10.1016/j.molstruc.2016.06.026

MNQ derivative D21 protects against LPS-induced inflammatory damage in bovine ovarian follicular GCs in vitro via the steroid biosynthesis signaling pathway

Xiaofeng Yang, Xiaowei Qin, Kai Wang, Ermias Kebreab and Lihua Lyu

Theriogenology, 2023, 206, 149
DOI: 10.1016/j.theriogenology.2023.05.010

Chemical Composition, Antioxidant, and Cytotoxic Effects of Senna rugosa Leaf and Root Extracts on Human Leukemia Cell Lines

Cintia Miranda dos Santos, Debora da Silva Baldivia, David Tsuyoshi Hiramatsu de Castro, José Tarciso de Giffoni Carvalho, Alex Santos Oliveira, Paola dos Santos da Rocha, Jaqueline Ferreira Campos, Sikiru Olaitan Balogun, Caio Fernando Ramalho de Oliveira, Denise Brentan da Silva, Carlos Alexandre Carollo, Kely de Picoli Souza and Edson Lucas dos Santos

Pharmaceuticals, 2024, 17, 974
DOI: 10.3390/ph17080974

Synthesis of Bioactive 3,4-Dihydro-2H-naphtho[2,3-b][1,4]oxazine-5,10-dione and 2,3,4,5-Tetrahydro-1H-naphtho[2,3-b]azepine-6,11-dione Derivatives via the Copper-Catalyzed Intramolecular Coupling Reaction

Hengyao You, Srinivas Rao Vegi, Chandraiah Lagishetti, Shuo Chen, R. Santhosh Reddy, Xiaohong Yang, Jian Guo, Chenhui Wang and Yun He

J. Org. Chem., 2018, 83, 4119
DOI: 10.1021/acs.joc.8b00020

Biological Activity of Naphthoquinones Derivatives in the Search of Anticancer Lead Compounds

Alexandra G. Durán, Nuria Chinchilla, Ana M. Simonet, M. Teresa Gutiérrez, Jorge Bolívar, Manuel M. Valdivia, José M. G. Molinillo and Francisco A. Macías

Toxins, 2023, 15, 348
DOI: 10.3390/toxins15050348

A new approach for the synthesis of novel naphthoquinone chalcone hybrid compounds

Ha-Thanh Nguyen, Tuyet Anh Dang Thi, Phuong Hoang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Anh Nguyen Tuan, Tu Anh Le Thi and Tuyen Van Nguyen

Tetrahedron Letters, 2021, 81, 153337
DOI: 10.1016/j.tetlet.2021.153337

Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects

Halilibrahim Ciftci, Belgin Sever, Nusret Kaya, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Molecules, 2022, 28, 77
DOI: 10.3390/molecules28010077

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment

Halilibrahim Ciftci, Belgin Sever, Firdevs Ocak, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hasan DeMirci, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Molecules, 2022, 27, 693
DOI: 10.3390/molecules27030693

Efforts in Bioprospecting Research: A Survey of Novel Anticancer Phytochemicals Reported in the Last Decade

Saheed O. Anifowose, Wejdan S. N. Alqahtani, Badr A. Al-Dahmash, Florenz Sasse, Maroua Jalouli, Mourad A. M. Aboul-Soud, Ahmed Y. Badjah-Hadj-Ahmed and Yasser A. Elnakady

Molecules, 2022, 27, 8307
DOI: 10.3390/molecules27238307

Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies

Ratchanok Pingaew, Veda Prachayasittikul, Apilak Worachartcheewan, Chanin Nantasenamat, Supaluk Prachayasittikul, Somsak Ruchirawat and Virapong Prachayasittikul

European Journal of Medicinal Chemistry, 2015, 103, 446
DOI: 10.1016/j.ejmech.2015.09.001

A convenient synthetic approach to dioncoquinone B and related compounds

Ekaterina A. Khmelevskaya and Dmitry N. Pelageev

Tetrahedron Letters, 2019, 60, 1022
DOI: 10.1016/j.tetlet.2019.03.016

Aromatase inhibitory, anti-proliferative, and apoptosis-inducing effects of naphthoquinone-triazole derivatives for potential anti-breast cancer agents: In vitro and molecular docking studies

Sakdiphong Punpai, Panupong Mahalapbutr, Ronnakorn Leechaisit, Khin Soe Win, Veda Prachayasittikul, Wanlaya Tanechpongtamb, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul and Ratchanok Pingaew

Biochemical and Biophysical Research Communications, 2026, 816, 153683
DOI: 10.1016/j.bbrc.2026.153683

Direct C−H Radical Alkylation of 1,4‐Quinones

Maxime Donzel, Deniz Karabiyikli, Leandro Cotos, Mourad Elhabiri and Elisabeth Davioud‐Charvet

Eur J Org Chem, 2021, 2021, 3622
DOI: 10.1002/ejoc.202100452

Synthetic Naphthoquinone Derivatives as Anticancer Agents in Ovarian Cancer: Cytotoxicity Assay and Investigation of Possible Biological Mechanisms Action

Renata Dalmaschio Daltoé, Leticia Batista Azevedo Rangel, Maicon Delarmelina, Klesia Pirola Madeira, Marcella Leite Porto, Silvana Santos Meirelles, Isabella dos Santos Guimarães, Éclair Venturini Filho, Alan Reinke Pereira, Rafael de Queiroz Ferreira, Gabriel Fernandes Souza dos Santos, Izabela de França Schaffel, José Walkimar de Mesquita Carneiro, Artur M. S. Silva and Sandro José Greco

Chemistry & Biodiversity, 2023, 20
DOI: 10.1002/cbdv.202200807

Soil sterilization accumulates higher content of antibacterial compound and recruits beneficial fungus for konjac soft rot disease management by multi-omics analyses

Chengfen Nong, Sauban Musa Jibril, Xinyun Yang, Lu Huang, Hao Qu, Xingrun Yang, Ruoping Wang, Xiaojuan Wu, Chengyun Li and Yi Wang

BMC Plant Biol, 2025, 25
DOI: 10.1186/s12870-025-07985-7

Metal-Free C–H Sulfamidation of 1,4-Naphthoquinone in Water

Pallaba Ganjan Dalai, Swayamprava Swain, Soumya Mohapatra and Niranjan Panda

J. Org. Chem., 2023, 88, 13760
DOI: 10.1021/acs.joc.3c01409

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

Borja Guerra, Patricia Martín-Rodríguez, Juan Carlos Díaz-Chico, Grant McNaughton-Smith, Sandra Jiménez-Alonso, Idaira Hueso-Falcón, Juan Carlos Montero, Rosa Blanco, Javier León, Germán Rodríguez-González, Ana Estévez-Braun, Atanasio Pandiella, Bonifacio Nicolás Díaz-Chico and Leandro Fernández-Pérez

Oncotarget, 2017, 8, 29679
DOI: 10.18632/oncotarget.11425

Reactive Chemicals and Electrophilic Stress in Cancer: A Minireview

Vehary Sakanyan

High-Throughput, 2018, 7, 12
DOI: 10.3390/ht7020012

Preparation of Novel Homodimers Derived from Cytotoxic Isoquinolinequinones. A Twin Drug Approach

Juana Ibacache, Judith Faundes, Margarita Montoya, Sophia Mejías and Jaime Valderrama

Molecules, 2018, 23, 439
DOI: 10.3390/molecules23020439

Design, Synthesis, and Antitumor Activity of a Series of Novel 4-(Aromatic Sulfonyl)-1-oxa-4-azaspiro[4.5]deca-6,9-dien-8-ones

Naiguo Xing, Chen Chen, Qiu Zhong, Shilong Zheng, Guangdi Wang and Ling He

Molecules, 2020, 25, 5459
DOI: 10.3390/molecules25225459

CF3-Bis-TEMPO-Vis: New Visible Light Active Bis-Benzimidazolequinone Alkoxyamine

Patrick Kielty, Pau Farràs, Dennis A. Smith and Fawaz Aldabbagh

Molbank, 2021, 2021, M1300
DOI: 10.3390/M1300

Loach embryos prooxidant-antioxidant status under the influence of amide derivatives of 1,4-naphthoquinone

A. O. Bezkorovayny, A. R. Zyn and N. M. Harasym

Ukr.Biochem.J, 2016, 88, 46
DOI: 10.15407/ubj88.03.046

Phragmunis a suppresses glioblastoma through the regulation of MCL1-FBXW7 by blocking ELK1-SRF complex-dependent transcription

Guo-dong Huang, Ping Cui, Guo-Xu Ma, Fan-fan Chen, Ze-bin Chen, Xue-juan Li, Zi-jun Liao, Wei-ping Li, Zong-yang Li and Lei Chen

Neurochemistry International, 2021, 147, 105051
DOI: 10.1016/j.neuint.2021.105051

Ontogeny and individual and group parameters of Cirsium erisithales (Jacq.) Scop. (Asteraceae) in the Ukrainian Carpathians

V. Kobiv

VLUBS, 2025, 10
DOI: 10.30970/vlubs.2024.93.02

An improved method for the preparation of β-lapachone:2-hydroxypropyl-β-cyclodextrin inclusion complexes

Caroline Deckmann Nicoletti, Marcella de Sá Haddad Queiroz, Carolina Guimarães de Souza Lima, Fernando de Carvalho da Silva, Debora Omena Futuro and Vitor Francisco Ferreira

Journal of Drug Delivery Science and Technology, 2020, 58, 101777
DOI: 10.1016/j.jddst.2020.101777

A Green Multicomponent Domino Mannich‐Michael Reaction to Synthesize Novel Naphthoquinone‐Polyphenols with Antiproliferative and Antioxidant Activities

Eclair Venturini Filho, Mariana K. Antoniazi, Rafael Q. Ferreira, Gabriel F. S. dos Santos, Claudia Pessoa, Celina J. Guimarães, José B. Vieira Neto, Artur M. S. Silva and Sandro J. Greco

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200442

Methylene Thiazolidinediones as Alkylation Reagents in Catalytic C–H Functionalization: Rapid Access to Glitazones

Youjung Byun, Kyeongwon Moon, Jihye Park, Prithwish Ghosh, Neeraj Kumar Mishra and In Su Kim

Org. Lett., 2022, 24, 8578
DOI: 10.1021/acs.orglett.2c03677

Montmorillonite K-10 catalyzed Mannich reaction: Synthesis of aminonaphthoquinone derivatives from Lawsone

Sankaranarayanan Jayashree and Kalegowda Shivashankar

Synthetic Communications, 2018, 48, 1805
DOI: 10.1080/00397911.2018.1466334

Exploration of brominated Plastoquinone analogs: Discovery and structure-activity relationships of small antimicrobial lead molecules

Mahmut Yıldız, Nilüfer Bayrak, Hatice Yıldırım, Emel Mataracı-Kara, Deepak Shilkar, Venkatesan Jayaprakash and Amaç Fatih Tuyun

Bioorganic Chemistry, 2021, 116, 105316
DOI: 10.1016/j.bioorg.2021.105316

Synthesis and characterization of some 2-quinonyl piperazine derivatives

Sibel Sahinler Ayla and Gulay Pasaoglu Gonul

Phosphorus, Sulfur, and Silicon and the Related Elements, 2022, 197, 943
DOI: 10.1080/10426507.2022.2047968

Metal(II) complexes of bioactive aminonaphthoquinone-based ligand: synthesis, characterization and BSA binding, DNA binding/cleavage, and cytotoxicity studies

A. Kosiha, C. Parthiban and Kuppanagounder P. Elango

Journal of Coordination Chemistry, 2018, 71, 1560
DOI: 10.1080/00958972.2018.1461846

DFT Study on Antioxidant Action Mechanisms of Naphthoquinone-Urazole Hybrids

Dilara ÖZBAKIR IŞIN

Cumhuriyet Science Journal, 2018, 39, 734
DOI: 10.17776/csj.454294

Design, In Silico Screening, Synthesis, and In Vitro Assessment of 1,4-Naphthoquinone-Tethered Hybrid Molecules to Explore Their Anticancer and Antimicrobial Potential

Satyam Srivastava, Harish Chandra Upadhyay, Pooja Goswami, Biplob Koch, Hardesh Kumar Maurya, Mayank Rashmi and Alok Sharma

ACS Omega, 2025, 10, 41158
DOI: 10.1021/acsomega.5c03820

Mn(II), Co(II), and Cu(II) complexes of the iodo derivative of “Heena”: synthesis, characterization, X-crystal structures, and anticancer activity

Sunita Salunke-Gawali, Manisha Gaikwad, Vivek Mokashi, Dipali N. Lande, Shridhar P. Gejji, Harsha Ashtekar and Ray J. Butcher

Inorganica Chimica Acta, 2025, 588, 122837
DOI: 10.1016/j.ica.2025.122837

Unlocking the potential of 1,4-naphthoquinones: A comprehensive review of their anticancer properties

Eduardo Angulo-Elizari, Andreina Henriquez-Figuereo, Cristina Morán-Serradilla, Daniel Plano and Carmen Sanmartín

European Journal of Medicinal Chemistry, 2024, 268, 116249
DOI: 10.1016/j.ejmech.2024.116249

Naphthoquinone-derived polyol macrolides from natural sources

V. A. Alferova, M. V. Shuvalov, V. A. Korshun and A. P. Tyurin

Russ Chem Bull, 2019, 68, 955
DOI: 10.1007/s11172-019-2506-3

Structural Changes Induced by Quinones: High‐Resolution Microwave Study of 1,4‐Naphthoquinone

Shefali Saxena, Sanjana Panchagnula, M. Eugenia Sanz, Cristóbal Pérez, Luca Evangelisti and Brooks H. Pate

ChemPhysChem, 2020, 21, 2579
DOI: 10.1002/cphc.202000665

Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance

Paloma Begines, Lucía Sevilla-Horrillo, Adrián Puerta, Rebecca Puckett, Samuel Bayort, Irene Lagunes, Inés Maya, José M. Padrón, Óscar López and José G. Fernández-Bolaños

Pharmaceuticals, 2020, 13, 358
DOI: 10.3390/ph13110358

A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity

Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita and Masami Otsuka

Chem. Pharm. Bull., 2022, 70, 477
DOI: 10.1248/cpb.c21-01087

Synthesis of the bioactive fungal natural product daldiquinone

Dilgam Ahmadli and Yunus Emre Türkmen

Tetrahedron Letters, 2022, 100, 153877
DOI: 10.1016/j.tetlet.2022.153877

Metal complexes of naphthoquinone based ligand: synthesis, characterization, protein binding, DNA binding/cleavage and cytotoxicity studies

A. Kosiha, C. Parthiban, Samuele Ciattini, Laura Chelazzi and Kuppanagounder P. Elango

Journal of Biomolecular Structure and Dynamics, 2018, 36, 4170
DOI: 10.1080/07391102.2017.1413423

Synthesis and Antitumor Evaluation of Hybrids of 5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates and Carbohydrates

Wanderson A da Silva, Luiz CRP da Silva, Vinicius R Campos, Maria CBV de Souza, Vitor F Ferreira, Ângela CPB dos Santos, Plínio C Sathler, Gabriella S de Almeida, Flaviana RF Dias, Lucio M Cabral, Rodrigo BV de Azeredo and Anna C Cunha

Future Med. Chem., 2018, 10, 527
DOI: 10.4155/fmc-2017-0173

Electrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green, and Efficient Access to Cytotoxic Compounds

Emilay B. T. Diogo, Fábio G. Delolo, Gabriela A. P. Graça, Esther R. S. Paz, Ícaro A. O. Bozzi, Renata Diniz, Juliano P. Passos, Tulio Matencio, Liane K. Soares, Diego Alves, Pedro M. S. Costa, Claudia Pessoa, Cynthia L. M. Pereira, Lutz Ackermann and Eufrânio N. da Silva Júnior

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300506

The diverse mechanisms and anticancer potential of naphthoquinones

Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes and Floriano Paes Silva-Jr

Cancer Cell Int, 2019, 19
DOI: 10.1186/s12935-019-0925-8

Natural Urease Inhibitors Reduce the Severity of Disease Symptoms, Dependent on the Lifestyle of the Pathogens

Lala Aliyeva-Schnorr, Carola Schuster and Holger B. Deising

JoF, 2023, 9, 708
DOI: 10.3390/jof9070708

Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Naphthoquinone‐Triazole Hybrids as Potential FGFR1 Tyrosine Kinase Inhibitors

Ronnakorn Leechaisit, Panupong Mahalapbutr, Utid Suriya, Pattamaporn Sukonthasakorn, Veda Prachayasittikul, Prasit Mandi, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul and Ratchanok Pingaew

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202400813

Schiff bases-based metallo complexes and their crucial role in the realm of pharmacology. A review

Raji Sankar and T.M. Sharmila

Results in Chemistry, 2023, 6, 101179
DOI: 10.1016/j.rechem.2023.101179

Anticancer Activity of 2‐Amino‐substituted‐1,4‐naphthoquinone Derivatives in Ovarian Cancer Cells

Sujeong Shin, Haneul Lee, Cheolmin Jeon, Umma Hafsa Preya, Jung‐Hye Choi and Jeong Ho Park

Bulletin Korean Chem Soc, 2017, 38, 1411
DOI: 10.1002/bkcs.11315

Studies on the interaction of mononuclear metal(II) complexes of amino‑naphthoquinone with bio-macromolecules

A. Kosiha, Kong Mun Lo, C. Parthiban and Kuppanagounder P. Elango

Materials Science and Engineering: C, 2019, 94, 778
DOI: 10.1016/j.msec.2018.10.021

Asymmetric Formal Coupling of β-Ketoesters with Quinones Promoted by a Chiral Bifunctional N-Heterocyclic Olefin

Sijing Wang, Jia Yang, Hongkun Zeng, Yuqiao Zhou, Fei Wang, Xiaoming Feng and Shunxi Dong

Org. Lett., 2023, 25, 7247
DOI: 10.1021/acs.orglett.3c02885

Naphthoquinones and derivatives as potential anticancer agents: An updated review

Md Mominur Rahman, Md Rezaul Islam, Shopnil Akash, Sheikh Shohag, Limon Ahmed, Fatema Akter Supti, Abdur Rauf, Abdullah S.M. Aljohani, Waleed Al Abdulmonem, Anees Ahmed Khalil, Rohit Sharma and Muthu Thiruvengadam

Chemico-Biological Interactions, 2022, 368, 110198
DOI: 10.1016/j.cbi.2022.110198

Synthesis of Methoxy Analogues of Coenzyme Q10 Metabolites from Parsley Seed Extracts via Baeyer–Villiger Rearrangement of Carbonyl-Substituted Polyalkoxybenzenes

Dmitry V. Demchuk, Olga I. Adaeva, Dmitry V. Tsyganov, Darina I. Nasyrova, Roman A. Dolotov, Еgor А. Muravsky, Alexander E. Varakutin, Alexander V. Samet and Victor V. Semenov

Synthesis, 2024, 56, 2549
DOI: 10.1055/s-0043-1775368

Synthesis of Succinimide-Containing Chromones, Naphthoquinones, and Xanthones under Rh(III) Catalysis: Evaluation of Anticancer Activity

Sang Hoon Han, Saegun Kim, Umasankar De, Neeraj Kumar Mishra, Jihye Park, Satyasheel Sharma, Jong Hwan Kwak, Sangil Han, Hyung Sik Kim and In Su Kim

J. Org. Chem., 2016, 81, 12416
DOI: 10.1021/acs.joc.6b02577

Synthesis and characterization of Mannich bases of lawsone and their anticancer activity

Pratik Nariya, Falguni Shukla, Hitarthi Vyas, Ranjitsinh Devkar and Sonal Thakore

Synthetic Communications, 2020, 50, 1724
DOI: 10.1080/00397911.2020.1755440

Synthesis, characterization and separation of chiral and achiral diastereomers of Schiff base Pd(II) complex: A comparative study of their DNA- and HSA-binding

Zahra Kazemi, Hadi Amiri Rudbari, Mehdi Sahihi, Valiollah Mirkhani, Majid Moghadam, Sharam Tangestaninejad, Iraj Mohammadpoor-Baltork, Gholamhassan Azimi, Sajjad Gharaghani and Abolghasem Abbasi Kajani

Journal of Photochemistry and Photobiology B: Biology, 2016, 163, 246
DOI: 10.1016/j.jphotobiol.2016.08.035

Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells

Hauke Löcken, Cinzia Clamor and Klaus Müller

J. Nat. Prod., 2018, 81, 1636
DOI: 10.1021/acs.jnatprod.8b00247

In vitro production of reactive oxygen species (ROS) by sampangine

Hamid R. Nasiri, Katharina Hohmann, Melissa G. Hatemler, Alois Plodek, Franz Bracher and Harald Schwalbe

Med Chem Res, 2017, 26, 1170
DOI: 10.1007/s00044-017-1835-8

C–H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)2Zn: Synthesis and Antiproliferative Evaluation

Jing Li, Xiaofei Zhang, Haoyue Xiang, Linjiang Tong, Fang Feng, Hua Xie, Jian Ding and Chunhao Yang

J. Org. Chem., 2017, 82, 6795
DOI: 10.1021/acs.joc.7b00940

HNC0014, a Multi-Targeted Small-Molecule, Inhibits Head and Neck Squamous Cell Carcinoma by Suppressing c-Met/STAT3/CD44/PD-L1 Oncoimmune Signature and Eliciting Antitumor Immune Responses

Jih-Chin Lee, Alexander T.H. Wu, Jia-Hong Chen, Wen-Yen Huang, Bashir Lawal, Ntlotlang Mokgautsi, Hsu-Shan Huang and Ching-Liang Ho

Cancers, 2020, 12, 3759
DOI: 10.3390/cancers12123759

Synthesis of New 1,4-Naphthoquinone Fluorosulfate Derivatives and the Study of Their Biological and Electrochemical Properties

Natalia V. Aseeva, Nadezhda V. Danilenko, Evgenii V. Plotnikov, Elena I. Korotkova, Olga I. Lipskikh, Anna N. Solomonenko, Alina V. Erkovich, Daria D. Eskova and Andrei I. Khlebnikov

IJMS, 2024, 25, 12245
DOI: 10.3390/ijms252212245

Acid-Catalyzed Heterocyclization of Trialkylnaphthazarin Thioglucosides in Angular Quinone-Carbohydrate Tetracycles

Y. E. Sabutskii, V. A. Denisenko, R. S. Popov and S. G. Polonik

Russ J Org Chem, 2019, 55, 147
DOI: 10.1134/S1070428019020040

Unveiling interactions between DNA and cytotoxic 2-arylpiperidinyl-1,4-naphthoquinone derivatives: A combined electrochemical and computational study

Christian Espinosa-Bustos, Camila Canales, Galo Ramírez, Pablo Jaque and Cristian O. Salas

Arabian Journal of Chemistry, 2020, 13, 2233
DOI: 10.1016/j.arabjc.2018.04.008

Synthesis and X-ray diffraction analysis of coenzyme Q derivatives obtained from natural polyalkoxyallylbenzenes

Dmitry V. Tsyganov, Dmitry V. Demchuk, Olga I. Adaeva, Leonid D. Konyushkin, Mikhail E. Minyaev, Victor N. Khrustalev and Victor V. Semenov

Mendeleev Communications, 2023, 33, 539
DOI: 10.1016/j.mencom.2023.06.032

Phenoxy‐ and Phenylamino‐Heterocyclic Quinones: Synthesis and Preliminary Anti‐Pancreatic Cancer Activity

Patricio Sánchez, Cristian O. Salas, Sebastián Gallardo‐Fuentes, Alondra Villegas, Nicolás Veloso, Jessica Honores, Martyn Inman, Mauricio Isaacs, Renato Contreras, Christopher J. Moody, Jonathan Cisterna, Iván Brito and Ricardo A. Tapia

Chemistry & Biodiversity, 2022, 19
DOI: 10.1002/cbdv.202101036

Naphthoquinone-induced arylation inhibits Sirtuin 7 activity

Valentina Sirri, Jérémy Berthelet, Oliver Brookes and Pascal Roussel

Journal of Cell Science, 2022, 135
DOI: 10.1242/jcs.259207

Probing the Strength and Mechanism of Binding Between Amifampridine and Calf Thymus DNA

Samira Sharifinia, Farshid Hajibabaei, Sadegh Salehzadeh, Neda Hosseinpour Moghadam and Sadegh Khazalpour

DNA and Cell Biology, 2020, 39, 2134
DOI: 10.1089/dna.2020.5618

A novel naphthoquinone compound triggers DNA damage-induced apoptosis on cholangiocarcinoma through upregulation of BAX

Gizem Bulut, Merve Kayis, Dilan Gezer, Zeliha Gokmen, Zelal Adiguzel, Chiara Raggi and Engin Ulukaya

Med Oncol, 2025, 42
DOI: 10.1007/s12032-025-02927-7

Novel menadione hybrids: Synthesis, anticancer activity, and cell‐based studies

Chakka Vara Prasad, Vadithe Lakshma Nayak, Sistla Ramakrishna and Uppuluri Venkata Mallavadhani

Chem Biol Drug Des, 2018, 91, 220
DOI: 10.1111/cbdd.13073

Switching Futile para‐Quinone to Efficient Reactive Oxygen Species Generator: Ubiquitin‐Specific Protease‐2 Inhibition, Electrocatalysis, and Quantification

Pushparathinam Gopinath, Atif Mahammed, Tal Eilon‐Shaffer, Mickal Nawatha, Shimrit Ohayon, Doron Shabat, Zeev Gross and Ashraf Brik

ChemBioChem, 2017, 18, 1683
DOI: 10.1002/cbic.201700330

Exponential Molecular Amplification by H2O2‐Mediated Autocatalytic Deprotection of Boronic Ester Probes to Redox Cyclers

Justine Pallu, Charlie Rabin, Geordie Creste, Mathieu Branca, François Mavré and Benoît Limoges

Chemistry A European J, 2019, 25, 7534
DOI: 10.1002/chem.201900627

Evaluation of DNA interaction, free radical scavenging and biologically active compounds of thermally stable p-tolylmethanamine Schiff bases and their binary Co(II) and Ni(II) complexes

Dasari Shiva Shankar, Nirmala Ganji, Sreenu Daravath, Kadtala Venkateswarlu and Shiva Raj

Chemical Data Collections, 2020, 28, 100439
DOI: 10.1016/j.cdc.2020.100439

(3,3’-Methylene)bis-2-hydroxy-1,4-naphthoquinones induce cytotoxicity against DU145 and PC3 cancer cells by inhibiting cell viability and promoting cell cycle arrest

Paula Priscilla de Freitas, Ruan Carlos Busquet Ribeiro, Isabella dos Santos Guimarães, Caroline S. Moreira, David R. Rocha, Fernando de Carvalho da Silva, Vitor Francisco Ferreira and Etel Rodrigues Pereira Gimba

Mol Biol Rep, 2021, 48, 3253
DOI: 10.1007/s11033-021-06406-w

Synthesis, Electrochemistry, DFT Calculations, Antimicrobial Properties and X‐ray Crystal Structures of Some NH‐ and/or S‐ Substituted‐1,4‐quinones

Aysecik Kacmaz, Elif Turker Acar, Gulten Atun, Kerem Kaya, Belgi Diren Sigirci and Funda Bagcigil

ChemistrySelect, 2018, 3, 8615
DOI: 10.1002/slct.201801155

Thiophene Analogue of Isotanshinone‐II Nucleus: A Novel Approach towards the Synthesis of Phenanthro[4,3‐b]‐thiophene‐4,5‐dione and Phenanthro[3,4‐b]thiophene‐4,5‐dione Derivatives

Aparna Sarkar, Rumpa Das and Gandhi K. Kar

ChemistrySelect, 2018, 3, 11422
DOI: 10.1002/slct.201802652

Regiodivergent oxidation of alkoxyarenes by hypervalent iodine/oxone® system

Hideyasu China, Kokoro Tanihara, Hirotaka Sasa, Kotaro Kikushima and Toshifumi Dohi

Catalysis Today, 2020, 348, 2
DOI: 10.1016/j.cattod.2019.08.060

Cytotoxic activity of quinolinequinones in cancer: In vitro studies, molecular docking, and ADME/PK profiling

Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz Goler, Deepak Shilkar, Subodh Mondal, Vinay N. Basavanakatti, Hatice Yıldırım, Mahmut Yıldız, Hülya Çelik Onar, Nilüfer Bayrak, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Chem Biol Drug Des, 2023, 102, 1133
DOI: 10.1111/cbdd.14314

Novel anticancer hybrids from diazen-1-ium-1,2-diolate nitric oxide donor and ROS inducer plumbagin: Design, synthesis and biological evaluations

Na Bao, Jinfeng Ou, Na Li, Pian Zou, Jianbo Sun and Li Chen

European Journal of Medicinal Chemistry, 2018, 154, 1
DOI: 10.1016/j.ejmech.2018.04.047

A Platform of Regioselective Methodologies to Access Polysubstituted 2‐Methyl‐1,4‐naphthoquinone Derivatives: Scope and Limitations

Elena Cesar Rodo, Liwen Feng, Mouhamad Jida, Katharina Ehrhardt, Max Bielitza, Jérémy Boilevin, Michael Lanzer, David Lee Williams, Don Antoine Lanfranchi and Elisabeth Davioud‐Charvet

Eur J Org Chem, 2016, 2016, 1982
DOI: 10.1002/ejoc.201600144

Synthesis and modification of noscapine derivatives as promising future anticancer agents

Faezeh Nemati, Amir ata Bahmani Asl and Peyman Salehi

Bioorganic Chemistry, 2024, 153, 107831
DOI: 10.1016/j.bioorg.2024.107831

Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells

Jing Ma, Chaemin Lim, Joshua R. Sacher, Bennett Van Houten, Wei Qian and Peter Wipf

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4828
DOI: 10.1016/j.bmcl.2015.06.073

Green synthesis of anticancerous honeycomb PtNPs clusters: Their alteration effect on BSA and HsDNA using fluorescence probe

Amol V. Pansare, Dnyaneshwar K. Kulal, Amol A. Shedge and Vishwanath R. Patil

Journal of Photochemistry and Photobiology B: Biology, 2016, 162, 473
DOI: 10.1016/j.jphotobiol.2016.07.021

The compound 2‐(naphthalene‐2‐thio)‐5,8‐dimethoxy‐1,4‐naphthoquinone induces apoptosis via reactive oxygen species‐regulated mitogen‐activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells

Jia‐Ru Wang, Gui‐Nan Shen, Ying‐Hua Luo, Xian‐Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling‐Qi Meng, Yi Zhang, Hao Wang, Jin‐Qian Li, Wan‐Ting Xu, Yang Liu, Hu‐Nan Sun, Ying‐Hao Han, Mei‐Hua Jin, Long‐Kui Cao and Cheng‐Hao Jin

Drug Development Research, 2018, 79, 295
DOI: 10.1002/ddr.21442

Hybrid Molecules Containing Naphthoquinone and Quinolinedione Scaffolds as Antineoplastic Agents

Ines Mancini, Jacopo Vigna, Denise Sighel and Andrea Defant

Molecules, 2022, 27, 4948
DOI: 10.3390/molecules27154948

Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones

Yuri E. Sabutski, Ekaterina S. Menchinskaya, Ludmila S. Shevchenko, Ekaterina A. Chingizova, Artur R. Chingizov, Roman S. Popov, Vladimir A. Denisenko, Valery V. Mikhailov, Dmitry L. Aminin and Sergey G. Polonik

Molecules, 2020, 25, 3577
DOI: 10.3390/molecules25163577

The crystal structure of 2-anilino-1,4-naphthoquinone, C10H11NO2

Mohammed A. Elmakki, Thato N. Taoana, Frederick J. F. Jacobs and Johan A. Venter

Zeitschrift für Kristallographie - New Crystal Structures, 2023, 238, 1101
DOI: 10.1515/ncrs-2023-0338

Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents

Guang Huang, Jin-Yun Dong, Qi-Jing Zhang, Qing-Qing Meng, Hui-Ran Zhao, Bao-Quan Zhu and Shao-Shun Li

European Journal of Medicinal Chemistry, 2019, 165, 160
DOI: 10.1016/j.ejmech.2019.01.005

Characterization of naphthoquinones as inhibitors of glutathione reductase and inducers of intracellular oxidative stress

Xiaowan Chen, Yan Ma, Ziming Yang, Dingjie Shen, Xia Li, Maowei Ni, Xiaoling Xu and Wei Chen

Redox Report, 2024, 29
DOI: 10.1080/13510002.2024.2432830

Tungstate-Catalyzed Selective Oxidation of Naphthalenols to Afford Diverse Products under Mild Conditions

Jing Liu and Zhilong Chen

Org. Lett., 2025, 27, 12012
DOI: 10.1021/acs.orglett.5c03647

Versatile iron-vitamin K3 derivative-based nanoscale coordination polymer augments tumor ferroptotic therapy

Zhicheng Zhang, Yawen Ding, Jinbiao Li, Li Wang, Xiaoyan Xin, Jing Yan, Jinhui Wu, Ahu Yuan and Yiqiao Hu

Nano Res., 2021, 14, 2398
DOI: 10.1007/s12274-020-3241-7

New strategies for the synthesis of naphthoquinones employing Cu(II) complexes: Crystal structures and cytotoxicity

Nathália F.B. Azeredo, Fabrícia P. Souza, Felipe C. Demidoff, Chaquip D. Netto, Jackson A.L.C. Resende, Roberto W.A. Franco, Pio Colepicolo, Ana M.C. Ferreira and Christiane Fernandes

Journal of Molecular Structure, 2018, 1152, 11
DOI: 10.1016/j.molstruc.2017.08.066

Simple avarone mimetics as selective agents against multidrug resistant cancer cells

Marko Jeremić, Milica Pešić, Jelena Dinić, Jasna Banković, Irena Novaković, Dejan Šegan and Dušan Sladić

European Journal of Medicinal Chemistry, 2016, 118, 107
DOI: 10.1016/j.ejmech.2016.04.011

Anticancer Tetrahydrocarbazoles: A Wide Journey from 2000 Till Date

Nitin Kumar and Pankaj Gupta

LDDD, 2024, 21, 421
DOI: 10.2174/1570180820666221028163319

The content of TBA-positive products in embryos of loach Misgurnus fossilis L. at different stages of development under the influence of amino acid derivatives of 1,4-naphthoquinone

A. Heneha, A. Tarnovska, M. Yaremchuk, A. Budevych and O. Semochko

VLUBS, 2024, 33
DOI: 10.30970/vlubs.2024.92.02

Methylated 1,2-naphthoquinone derivative SJ006 as an inhibitor of human glucose 6-phosphate dehydrogenase in non-small cell lung cancer cell lines

Makamas Chanda, Warinthorn Chavasiri, Panupong Mahalapbutr, Thanyada Rungrotmongkol, Poonlarp Cheepsunthorn and Chalisa Louicharoen Cheepsunthorn

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-20702-6

Cu(II) and Ni(II) Complexes of Anthracene‐Affixed Schiff Base: A Conflict between Covalent and Stacking Interactions with DNA Bases

Sellamuthu Kathiresan, Jamespandi Annaraj and Nattamai S. P. Bhuvanesh

ChemistrySelect, 2017, 2, 5475
DOI: 10.1002/slct.201700693

In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights

Halilibrahim Ciftci, Belgin Sever, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Pharmaceuticals, 2022, 15, 1266
DOI: 10.3390/ph15101266

Design, synthesis and anticancer activity of 2-amidomethoxy-1,4-naphthoquinones and its conjugates with Biotin/polyamine

Manoj Manickam, Pulla Reddy Boggu, Thanigaimalai Pillaiyar, Yeo Jin Nam, Md. Abdullah, Seung Jin Lee, Jong Seong Kang and Sang-Hun Jung

Bioorganic & Medicinal Chemistry Letters, 2021, 31, 127685
DOI: 10.1016/j.bmcl.2020.127685

Two-dimensional quantitative structure–activity relationship study of 1,4-naphthoquinone derivatives tested against HL-60 human promyelocytic leukaemia cells

M. C. A. Costa and M. M. C. Ferreira

SAR and QSAR in Environmental Research, 2017, 28, 325
DOI: 10.1080/1062936X.2017.1318301

New Insights into the Metabolic Profile and Cytotoxic Activity of Kigelia africana Stem Bark

Dimitrina Zheleva-Dimitrova, Rositsa Mihaylova, Maria Nikolova, Nisha Singh and Spiro Konstantinov

Molecules, 2025, 30, 1388
DOI: 10.3390/molecules30061388

Oxadiazole-substituted naphtho[2,3- b ]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structure−activity relationships of the tricyclic quinone skeleton and the oxadiazole substituent

Atila Basoglu, Simone Dirkmann, Nader Zahedi Golpayegani, Silke Vortherms, Jan Tentrop, Dominica Nowottnik, Helge Prinz, Roland Fröhlich and Klaus Müller

European Journal of Medicinal Chemistry, 2017, 134, 119
DOI: 10.1016/j.ejmech.2017.03.084

Successful Targeting of the Warburg Effect in Prostate Cancer by Glucose-Conjugated 1,4-Naphthoquinones

Sergey A. Dyshlovoy, Dmitry N. Pelageev, Jessica Hauschild, Ksenia L. Borisova, Moritz Kaune, Christoph Krisp, Simone Venz, Yurii E. Sabutskii, Ekaterina A. Khmelevskaya, Tobias Busenbender, Vladimir A. Denisenko, Natalia D. Pokhilo, Lyubov N. Atopkina, Markus Graefen, Hartmut Schlüter, Valentin A. Stonik, Carsten Bokemeyer, Victor Ph. Anufriev and Gunhild von Amsberg

Cancers, 2019, 11, 1690
DOI: 10.3390/cancers11111690

Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component domino reaction and evaluation of their cytotoxic activity

Tuyet Anh Dang Thi, Giang Le-Nhat-Thuy, Quynh Giang Nguyen Thi, Phuong Hoang Thi, Anh Nguyen Tuan, Ha Hoang Mai, Thanh Nguyen Ha, Tuan Anh Le and Tuyen Van Nguyen

Chem Heterocycl Comp, 2021, 57, 137
DOI: 10.1007/s10593-021-02884-9

Promising Antibacterial and Antifungal Agents Based on Thiolated Vitamin K3 Analogs: Synthesis, Bioevaluation, Molecular Docking

Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Emel Mataracı-Kara, Mohamed Osman Radwan, Ayse Tarbin Jannuzzi, Masami Otsuka, Mikako Fujita and Amaç Fatih TuYuN

Pharmaceuticals, 2022, 15, 586
DOI: 10.3390/ph15050586

Synthesis and anti-cancer activity of naphthalimide–organylselanyl conjugates

Rajkumar Ravi and Selvakumar Karuthapandi

Beilstein J. Org. Chem., 2026, 22, 416
DOI: 10.3762/bjoc.22.29

Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis

Katia M. Oliveira, Luna-Dulcey Liany, Rodrigo S. Corrêa, Victor M. Deflon, Marcia R. Cominetti and Alzir A. Batista

Journal of Inorganic Biochemistry, 2017, 176, 66
DOI: 10.1016/j.jinorgbio.2017.08.019

Recently Reported Ru-Metal Organic Coordination Complexes and Their Application (A Review)

Partha Sarathi Guin and Sanjay Roy

Russ J Gen Chem, 2022, 92, 1546
DOI: 10.1134/S1070363222080242

Design, synthesis, and biological activity of Plastoquinone analogs as a new class of anticancer agents

Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, Masami Otsuka, Mikako Fujita, Amaç Fatih Tuyun and Halil I. Ciftci

Bioorganic Chemistry, 2019, 92, 103255
DOI: 10.1016/j.bioorg.2019.103255

Identification of the naphthoquinone derivative inhibitors binding site in heat shock protein 90: an induced-fit docking, molecular dynamics and 3D-QSAR study

Claudio Godoy-Castillo, Nicolas Bravo-Acuña, Gloria Arriagada, Fernando Faunes, Roberto León and Jorge Soto-Delgado

Journal of Biomolecular Structure and Dynamics, 2021, 39, 5977
DOI: 10.1080/07391102.2020.1803134

Anti-proliferative and pro-apoptotic activity of glycosidic derivatives of lawsone in melanoma cancer cell

Mariana Nobre Farias de Franca, Raquel Geralda Isidório, João Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo José Alves and Cristiane Bani Corrêa

BMC Cancer, 2021, 21
DOI: 10.1186/s12885-021-08404-4

Protective effects of MNQ against Lipopolysaccharide-induced inflammatory damage in bovine ovarian follicular granulosa cells in Vitro

Xiaofeng Yang, Tong Guo, Zhangsheng Du, Xiaowei Qin, Kai Wang, Ermias Kebreab, Dong Wang and Lihua Lyu

The Journal of Steroid Biochemistry and Molecular Biology, 2023, 230, 106274
DOI: 10.1016/j.jsbmb.2023.106274

Design, Synthesis and SAR Study of Novel Spiro [Pyrimido[5,4‐b]Quinoline‐10,5′‐Pyrrolo[2,3‐d]Pyrimidine] Derivatives as Promising Anticancer Agents

Asha V. Chate, Sagar P. Kamdi, Amruta N. Bhagat, Chetan K. Jadhav, Amol Nipte, Aniket P. Sarkate, Shailee V. Tiwari and Charansingh H. Gill

Journal of Heterocyclic Chem, 2018, 55, 2297
DOI: 10.1002/jhet.3286

Aminated Quinolinequinones With EDG(s) as a Prostate Cancer Inhibitor: Mechanistic Insights and Pharmacokinetic Limitations

Ayse Tarbin Jannuzzi, Ayse Mine Yilmaz, Abanish Biswas, Subodh Mondal, Vinay N. Basavanakatti, Hatice Yıldırım, Mahmut Yıldız, Nilüfer Bayrak, Venkatesan Jayaprakash and Amaç Fatih TuYuN

Chemistry & Biodiversity, 2026, 23
DOI: 10.1002/cbdv.202501594

Synthetic Method to Form 2,2′-Bis(naphthoquinone) Compounds

Vishwajeet Jha, Navneet Goyal, Cheryl K. Stevens, Edwin Stevens and Jayalakshmi Sridhar

J. Org. Chem., 2017, 82, 13686
DOI: 10.1021/acs.joc.7b02501

Investigation of chemical reactivity of 2-alkoxy-1,4-naphthoquinones and their anticancer activity

Manoj Manickam, Pulla Reddy Boggu, Jungsuk Cho, Yeo Jin Nam, Seung Jin Lee and Sang-Hun Jung

Bioorganic & Medicinal Chemistry Letters, 2018, 28, 2023
DOI: 10.1016/j.bmcl.2018.04.060

CADD Methods for Developing Novel Compounds Synthesized to Inhibit Tyrosine Kinase Receptors

Amal Bouribab, Abdelkbir Errougui and Samir Chtita

CTMC, 2025, 25, 1141
DOI: 10.2174/0115680266312422240712053821

Biophysical Evaluation of Water-Soluble Curcumin Encapsulated in β-Cyclodextrins on Colorectal Cancer Cells

Zhi Xuan Low, Michelle Yee Mun Teo, Fariza Juliana Nordin, Firli Rahmah Primula Dewi, Vijayaraj Kumar Palanirajan and Lionel Lian Aun In

IJMS, 2022, 23, 12866
DOI: 10.3390/ijms232112866

SuFEx‐Functionalized Quinones via Ruthenium‐Catalyzed C−H Alkenylation: A Potential Building Block for Bioactivity Valorization

Joyce C. de Oliveira, Breno U. Abreu, Esther R. S. Paz, Renata G. Almeida, João Honorato, Cauê P. Souza, Felipe Fantuzzi, Victor F. S. Ramos, Rubem F. S. Menna‐Barreto, Maria H. Araujo, Guilherme A. M. Jardim and Eufrânio N. da Silva Júnior

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400757

A novel series of chlorinated plastoquinone analogs: Design, synthesis, and evaluation of anticancer activity

Nilüfer Bayrak, Hatice Yıldırım, Mahmut Yıldız, Mohamed O. Radwan, Masami Otsuka, Mikako Fujita, Halil I. Ciftci and Amaç Fatih Tuyun

Chem Biol Drug Des, 2020, 95, 343
DOI: 10.1111/cbdd.13651

Synthesis and Antimicrobial, Antiproliferative Evaluation of Novel Quinolone and Conazole Analogues via Conventional and Microwave Techniques

Şule Ceylan, Yıldız Uygun Cebeci, Şengül Alpay Karaoğlu and Muhammed Altun

ChemistrySelect, 2021, 6, 9467
DOI: 10.1002/slct.202101840

Design, synthesis, anticancer and antioxidant activities of amide linked 1,4-disubstituted 1,2,3-triazoles

C.P. Kaushik, Jyoti Sangwan, Raj Luxmi, Devinder Kumar, Deepak Kumar, Ashutosh Das, Ashwani Kumar and Dharmendra Singh

Journal of Molecular Structure, 2021, 1226, 129255
DOI: 10.1016/j.molstruc.2020.129255

Rh‐Catalyzed [2 + 2 + 2] Cycloaddition of Linked Bis(Diynes) Ar‐C≡C‐C≡C‐(CH2)3‐C≡C‐C≡C‐Ar With Quinones: Synthesis and Photophysical Properties of Bis(Arylethynyl)‐Naphthoquinones and Anthraquinones

Luana A. Machado, Jianhua Han, Fábio G. Delolo, Joyce C. Oliveira, Breno U. Abreu, Hállen D. R. Calado, Joannes Krebs, Leibo Tan, Qing Ye, Tobias Groß, Christoph Lambert, Camille Latouche, Abdou Boucekkine, Jean‐François Halet, Holger Braunschweig, Todd B. Marder and Eufrânio N. da Silva Júnior

Chemistry A European J, 2026, 32
DOI: 10.1002/chem.202503173

Bioactive rinderol and cynoglosol isolated from Cynoglossum columnae Ten. in vitro root culture

Małgorzata Jeziorek, Harilaos Damianakos, Anna Kawiak, Agnieszka E. Laudy, Karolina Zakrzewska, Katarzyna Sykłowska-Baranek, Ioanna Chinou and Agnieszka Pietrosiuk

Industrial Crops and Products, 2019, 137, 446
DOI: 10.1016/j.indcrop.2019.04.046

ChemInform Abstract: Understanding Cancer and the Anticancer Activities of Naphthoquinones — A Review

Kevin W. Wellington

ChemInform, 2015, 46
DOI: 10.1002/chin.201520329

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells

Sergey A. Dyshlovoy, Dmitry N. Pelageev, Lea S. Jakob, Ksenia L. Borisova, Jessica Hauschild, Tobias Busenbender, Moritz Kaune, Ekaterina A. Khmelevskaya, Markus Graefen, Carsten Bokemeyer, Victor Ph. Anufriev and Gunhild von Amsberg

Pharmaceuticals, 2021, 14, 949
DOI: 10.3390/ph14100949

Synthesis, characterization and antiproliferative effects of naphtho [2,3-b] thiophen-4,9-quinone on bladder tumor cells

Gabriel Monteze Ferreira, Ana Paula Braga Lima, Guilherme Rocha Pereira, Glenda Nicioli da Silva and Geraldo Célio Brandão

Natural Product Research, 2023, 37, 2285
DOI: 10.1080/14786419.2022.2036143

Molecular docking and Anticancer Activity of Some Synthesized 1,4- naphthoquinone Derivatives against Human Cancer Cell Line

Amani A.S. Abdelaziz, Muhammad Nawaz, Ishraga Izzeldin, Haya A. Abubshait, Ahmed Alsadig, M.S. Gomaa, Samar A. Abubshait and Donya Alsewdan

Journal of Molecular Structure, 2023, 1275, 134702
DOI: 10.1016/j.molstruc.2022.134702

Development of solid dispersions of β-lapachone in PEG and PVP by solvent evaporation method

Klecia M. dos Santos, Raquel de Melo Barbosa, Fernanda Grace A. Vargas, Eduardo Pereira de Azevedo, Antônio Cláudio da Silva Lins, Celso A. Camara, Cícero F. S. Aragão, Tulio Flavio de Lima e Moura and Fernanda Nervo Raffin

Drug Development and Industrial Pharmacy, 2018, 44, 750
DOI: 10.1080/03639045.2017.1411942

Synthesis, antibacterial and antifungal evaluation of thio- or piperazinyl-substituted 1,4-naphthoquinone derivatives

Cemil Ibis, Zeliha Ozsoy-Gunes, Amac Fatih Tuyun, Sibel Sahinler Ayla, Hakan Bahar, Maryna V. Stasevych, Rostyslav Ya. Musyanovych, Olena Komarovska-Porokhnyavets and Volodymyr Novikov

Journal of Sulfur Chemistry, 2016, 37, 477
DOI: 10.1080/17415993.2016.1187734

A simple synthesis of natural spinazarins and their analogues

Dmitry N. Pelageev, Ksenia L. Borisova, Svetlana M. Kovach, Vyacheslav V. Makhankov and Victor Ph. Anufriev

Mendeleev Communications, 2023, 33, 231
DOI: 10.1016/j.mencom.2023.02.026

Copper-catalyzed three-component synthesis of aminonaphthoquinone–sulfonylamidine conjugates and in vitro evaluation of their antiproliferative activity

Thachapully D. Suja, K.V.L. Divya, Lakshma V. Naik, A. Ravi Kumar and Ahmed Kamal

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 2072
DOI: 10.1016/j.bmcl.2016.02.071

Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments

Laura Flores-Bocanegra, Huzefa A. Raja, Jeffrey W. Bacon, Amanda C. Maldonado, Joanna E. Burdette, Cedric J. Pearce and Nicholas H. Oberlies

J. Nat. Prod., 2021, 84, 771
DOI: 10.1021/acs.jnatprod.0c00856

Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation

Shengtao Xu, Hong Yao, Lingling Pei, Mei Hu, Dahong Li, Yangyi Qiu, Guangyu Wang, Liang Wu, Hequan Yao, Zheying Zhu and Jinyi Xu

European Journal of Medicinal Chemistry, 2017, 132, 310
DOI: 10.1016/j.ejmech.2017.03.055

Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells

Evgeny Pislyagin, Sergey Kozlovskiy, Ekaterina Menchinskaya, Ekaterina Chingizova, Galina Likhatskaya, Tatiana Gorpenchenko, Yuri Sabutski, Sergey Polonik and Dmitry Aminin

Bioorganic & Medicinal Chemistry, 2021, 31, 115975
DOI: 10.1016/j.bmc.2020.115975

Design, synthesis, and evaluation of N1,N3-dialkyldioxonaphthoimidazoliums as antibacterial agents against methicillin-resistant Staphylococcus aureus

Taewoo Kim, Shin-Yae Choi, Hee-Won Bae, Hyun Su Kim, Hoon Jeon, Haejun Oh, Sung-Hoon Ahn, Jongkook Lee, Young-Ger Suh, You-Hee Cho and Seok-Ho Kim

European Journal of Medicinal Chemistry, 2024, 272, 116454
DOI: 10.1016/j.ejmech.2024.116454

SYNTHESIS AND PREDICTION OF THE BIOLOGICAL ACTIVITY OF HETEROCYCLIC N-DERIVATIVES NAPHTHOQUINONE

N. V. Polish, N. G. Marintsova, L. R. Zhurakhivska, V. P. Novikov and M. V. Vovk

CTAS, 2019, 2, 69
DOI: 10.23939/ctas2019.01.069

Antifungal Activity of Selected Naphthoquinones and Their Synergistic Combination with Amphotericin B Against Cryptococcus neoformans H99

Naira Sulany Oliveira de Sousa, Juan Diego Ribeiro de Almeida, Linnek Silva da Rocha, Izabela de Mesquita Bárcia Moreira, Flávia da Silva Fernandes, Ani Beatriz Jackisch Matsuura, Kátia Santana Cruz, Emersom Silva Lima, Érica Simplício de Souza, Hagen Frickmann and João Vicente Braga de Souza

Antibiotics, 2025, 14, 602
DOI: 10.3390/antibiotics14060602

ML162 derivatives incorporating a naphthoquinone unit as ferroptosis/apoptosis inducers: Design, synthesis, anti-cancer activity, and drug-resistance reversal evaluation

Furong Ma, Yulong Li, Maohua Cai, Wenyan Yang, Zumei Wu, Jinyun Dong and Jiang-Jiang Qin

European Journal of Medicinal Chemistry, 2024, 270, 116387
DOI: 10.1016/j.ejmech.2024.116387

Production of Fungal Pigments: Molecular Processes and Their Applications

Lan Lin and Jianping Xu

JoF, 2022, 9, 44
DOI: 10.3390/jof9010044

Norcyanine-Carbamates Are Versatile Near-Infrared Fluorogenic Probes

Syed Muhammad Usama, Fuyuki Inagaki, Hisataka Kobayashi and Martin J. Schnermann

J. Am. Chem. Soc., 2021, 143, 5674
DOI: 10.1021/jacs.1c02112

Quinonoid compounds via reactions of lawsone and 2-aminonaphthoquinone with α-bromonitroalkenes and nitroallylic acetates: Structural diversity by C-ring modification and cytotoxic evaluation against cancer cells

Thekke V. Baiju, Renata G. Almeida, Sudheesh T. Sivanandan, Carlos A. de Simone, Lucas M. Brito, Bruno C. Cavalcanti, Claudia Pessoa, Irishi N.N. Namboothiri and Eufrânio N. da Silva Júnior

European Journal of Medicinal Chemistry, 2018, 151, 686
DOI: 10.1016/j.ejmech.2018.03.079

Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells

Aysecik Kacmaz, Nahide Gulsah Deniz, Serdar Goksin Aydinli, Cigdem Sayil, Evren Onay-Ucar, Elif Mertoglu and Nazli Arda

Open Chemistry, 2019, 17, 337
DOI: 10.1515/chem-2019-0030

Unsaturated Phosphonates as Hauser Acceptors for the Synthesis of Phosphonylated Dihydroxynaphthalenes and Naphthoquinones

Atul Kumar Chaturvedi and Namrata Rastogi

J. Org. Chem., 2016, 81, 3303
DOI: 10.1021/acs.joc.6b00312

6-[(1,4-Naphthoquinone-2-yl)methyl]thio–Glucose Conjugates, a Novel Targeted Approach for Advanced Prostate Cancer

Tobias Busenbender, Dmitry N. Pelageev, Jessica Hauschild, Moritz Kaune, Lukas Boeckelmann, Christoph Krisp, Mohamed E. Elsesy, Alexandra Zielinski, Thomas Mair, Maria Riedner, Ayham Moustafa, Simone Venz, Malte Kriegs, Konstantin Hoffer, Yuri E. Sabutski, Ksenia L. Borisova, Nadja Strewinsky, Svetlana M. Kovach, Ekaterina A. Khmelevskaya, Hartmut Schlüter, Victor Ph Anufriev, Derya Tilki, Markus Graefen, Wael Y. Mansour, Carsten Bokemeyer, Sergey A. Dyshlovoy and Gunhild von Amsberg

Molecular Cancer Therapeutics, 2025, 24, 1331
DOI: 10.1158/1535-7163.MCT-24-0955

1,4 -naphthoquinone derivatives with anticancer potential: A comprehensive review

Atri Sarker Mumu, Rashmia Nargis Reyda and Nazmul Qais

European Journal of Medicinal Chemistry Reports, 2026, 17, 100326
DOI: 10.1016/j.ejmcr.2026.100326

Monasone Naphthoquinone Biosynthesis and Resistance in Monascus Fungi

Mu Li, Lijing Kang, Xiaoli Ding, Jiao Liu, Qingpei Liu, Yanchun Shao, István Molnár, Fusheng Chen and B. Gillian Turgeon

mBio, 2020, 11
DOI: 10.1128/mBio.02676-19

Screening of 1,2-furanonaphthoquinones 1,2,3-1H-triazoles for glycosidases inhibitory activity and free radical scavenging potential: an insight in anticancer activity

Rafael F. Dantas, Mario R. Senger, Mariana F. C. Cardoso, Vitor F. Ferreira, Maria Cecília B. V. de Souza, Fernando de C. da Silva and Floriano P. Silva

Med Chem Res, 2019, 28, 1579
DOI: 10.1007/s00044-019-02396-4

Ультраструктура зародків в’юна за впливу новосинтезованих амідних похідних 1,4-нафтохінону

Аndriy Bezkorovaynyj, Alina Zyn, Nataliya Harasym and Dmytro Sanagursky

EENUBBS, 2019, 149
DOI: 10.29038/2617-4723-2016-337-12-149-156

Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug

Katia M. Oliveira, João Honorato, Felipe C. Demidoff, Mario S. Schultz, Chaquip D. Netto, Marcia R. Cominetti, Rodrigo S. Correa and Alzir A. Batista

Journal of Inorganic Biochemistry, 2021, 214, 111289
DOI: 10.1016/j.jinorgbio.2020.111289

Novel 2-amino-1,4-naphthoquinone hybrids: Design, synthesis, cytotoxicity evaluation and in silico studies

Maryam Gholampour, Hassan Seradj, Somayeh Pirhadi and Mehdi Khoshneviszadeh

Bioorganic & Medicinal Chemistry, 2020, 28, 115718
DOI: 10.1016/j.bmc.2020.115718

o-Iodoxybenzoic Acid-Initiated One-Pot Synthesis of 4-Arylthio-1,2-naphthoquinones, 4-Arylthio-1,2-diacetoxynaphthalenes, and 5-Arylthio-/5-Aminobenzo[a]phenazines

Abhaya Kumar Mishra and Jarugu Narasimha Moorthy

J. Org. Chem., 2016, 81, 6472
DOI: 10.1021/acs.joc.6b01105

Polyol-crafted superparamagnetic nanoparticles: Hyperthermia performance with histotoxicity assessment

Amol B. Pandhare, Swapnajit V. Mulik, Sandeep B. Somvanshi, Satish S. Phalake, Vishwajeet M. Khot, Nagesh B. Birajdar, Manikandan Ayyar, Hany Koheil, Yuanbin Zhang, Basem E. Keshta, AbdAllah A. Alotibi, Rajendra P. Patil and Sagar D. Delekar

Journal of the Indian Chemical Society, 2025, 102, 102195
DOI: 10.1016/j.jics.2025.102195