Issue 28, 2024

A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays

Abstract

Lateral flow immunoassay (LFIA), an affordable and rapid paper-based detection technology, is employed extensively in clinical diagnosis, environmental monitoring, and food safety analysis. The COVID-19 pandemic underscored the validity and adoption of LFIA in performing large-scale clinical and public health testing. The unprecedented demand for prompt diagnostic responses and advances in nanotechnology have fueled the rise of next-generation LFIA technologies. The utilization of nanoparticles to amplify signals represents an innovative approach aimed at augmenting LFIA sensitivity. This review probes the nanoparticle-assisted amplification strategies in LFIA applications to secure low detection limits and expedited response rates. Emphasis is placed on comprehending the correlation between the physicochemical properties of nanoparticles and LFIA performance. Lastly, we shed light on the challenges and opportunities in this prolific field.

Graphical abstract: A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays

Article information

Article type
Review Article
Submitted
21 4 2024
Accepted
12 6 2024
First published
13 6 2024

J. Mater. Chem. B, 2024,12, 6735-6756

A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays

F. Gao, S. Ye, L. Huang and Z. Gu, J. Mater. Chem. B, 2024, 12, 6735 DOI: 10.1039/D4TB00865K

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