Issue 35, 2022

Profoundly improved photostability of dimetronidazole by cocrystallization

Abstract

Dimetronidazole (DMZ), an veterinary antibiotic, exhibits poor photostability with only 80.38% potency remaining after exposure to illuminance of 4500 lux for 7 days. The photodegradation is accompanied by obvious color change. A 1 : 1 cocrystal of DMZ with saccharine exhibited profoundly improved photostability with 98.95% of DMZ remaining after 7 days under the same light exposure. Thus, this new cocrystal can be used to develop more stable drug products of DMZ.

Graphical abstract: Profoundly improved photostability of dimetronidazole by cocrystallization

Supplementary files

Article information

Article type
Paper
Submitted
29 4 2022
Accepted
01 8 2022
First published
01 8 2022

CrystEngComm, 2022,24, 6165-6171

Author version available

Profoundly improved photostability of dimetronidazole by cocrystallization

X. Hao, J. Li, C. Wang, X. Zhao, X. He and C. C. Sun, CrystEngComm, 2022, 24, 6165 DOI: 10.1039/D2CE00597B

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