Issue 31, 2021

A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation

Abstract

Phototherapy for cancer treatment has received much attention in recent years, and compounds with multiple anticancer mechanisms upon irradiation are particularly appealing. In this work, a nitro-anthraquinone group was attached to a biq (2,2′-biquinoline) ligand based Ru(II) complex, endowing the resultant Ru1 compound with multiple anticancer mechanisms upon 600 nm light irradiation. Ru1 can undergo biq ligand photodissociation, showing its potential as a photoactivated chemotherapy (PACT) agent. Moreover, a Ru(III) centre and an anthraquinone anion centre may be generated upon irradiation, which can further oxidize NADH/NADPH and generate O2˙, successfully eliciting photoredox catalysis and photodynamic therapy (PDT). Compared to the control complex Ru2 without the nitroanthraquinone group, Ru1 exhibited much enhanced photocytotoxicity towards a series of cancer cell lines and 3D multicellular spheroids upon red light irradiation.

Graphical abstract: A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation

Supplementary files

Article information

Article type
Paper
Submitted
01 4 2021
Accepted
04 7 2021
First published
05 7 2021

Dalton Trans., 2021,50, 10845-10852

A Ru-anthraquinone dyad with triple functions of PACT, photoredox catalysis and PDT upon red light irradiation

C. Zhang, X. Guo, X. Da, Z. Wang, X. Wang and Q. Zhou, Dalton Trans., 2021, 50, 10845 DOI: 10.1039/D1DT01088C

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