Issue 1, 2015

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Abstract

Heterocyclic arynes, or hetarynes, have been studied for over 100 years. However, challenges associated with observing these reactive species, as well as developing synthetically useful methods for their generation and trapping, have limited their use. This review provides a brief historical perspective on the field of hetarynes, in addition to a discussion of pyridyne and indolyne methodologies. Moreover, this review highlights the use of pyridynes, indolynes, and related strained intermediates in natural product synthesis.

Graphical abstract: Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

Article information

Article type
Feature Article
Submitted
16 8 2014
Accepted
04 9 2014
First published
05 9 2014

Chem. Commun., 2015,51, 34-45

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

A. E. Goetz, T. K. Shah and N. K. Garg, Chem. Commun., 2015, 51, 34 DOI: 10.1039/C4CC06445C

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