Issue 13, 2013

Electric-field induced mutation of DNA: a theoretical investigation of the GC base pair

Abstract

It is known that intense external electric fields affect the proton transfer (PT) reactions in simple chemical systems, such as hydrated chlorhydric acid or formic acid dimer. Accordingly, electric fields might be used to modulate the PT reactions responsible for the spontaneous mutation mechanism in DNA. In this contribution, we investigate the effect of these fields on the tautomeric equilibria of the guanine–cytosine (GC) base pair in order to gain further insight into this hypothesis. This task is performed with both density functional theory (DFT) and second-order Møller–Plesset (MP2) approaches. Our results demonstrate that electric fields not only drastically alter the rate constants of PT but also tune the mechanism of the PT reactions in the GC base pair.

Graphical abstract: Electric-field induced mutation of DNA: a theoretical investigation of the GC base pair

Supplementary files

Article information

Article type
Paper
Submitted
15 11 2012
Accepted
14 12 2012
First published
14 12 2012

Phys. Chem. Chem. Phys., 2013,15, 4548-4553

Electric-field induced mutation of DNA: a theoretical investigation of the GC base pair

J. P. Cerón-Carrasco and D. Jacquemin, Phys. Chem. Chem. Phys., 2013, 15, 4548 DOI: 10.1039/C2CP44066K

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