Issue 45, 2009

Solid-phase synthesis of protected α-amino phosphonic acid oligomers

Abstract

By establishing both a highly efficient phosphonamidate formation and a RuCp-catalyzed cleavage of an allyl linker, the solid-phase synthesis of Fmoc-(GlyP(OBn))6-OH/DIEA, a protected form of a new type of unnatural peptide α-amino phosphonic acid oligomer (APO), has been realized.

Graphical abstract: Solid-phase synthesis of protected α-amino phosphonic acid oligomers

Supplementary files

Article information

Article type
Communication
Submitted
22 6 2009
Accepted
30 9 2009
First published
14 10 2009

Chem. Commun., 2009, 6985-6987

Solid-phase synthesis of protected α-amino phosphonic acid oligomers

Y. Ishibashi and M. Kitamura, Chem. Commun., 2009, 6985 DOI: 10.1039/B912231A

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