Issue 16, 2024

Synthesis and characterization of safranal@MIL-88B(Fe) nanostructures and their preliminary anticancer and antibacterial characteristics

Abstract

Applications of metal–organic framework (MOF) nanostructures in biomedicine have rapidly expanded over the past decade. MOFs are characterized by their high functionality, surface area, and porosity, providing an ideal platform for several biomedical applications. This study explores the potential of a novel therapeutic approach for liver cancer, incorporating Safranal, a bioactive molecule derived from saffron, within the iron-based metal–organic framework (MOF), MIL-88B(Fe). The successfully loaded Safranal-MIL-88B(Fe) composite nanostructure was comprehensively characterized and tested for its effectiveness against HepG2 liver cancer cells. Furthermore, we investigated its antibacterial efficacy against Escherichia coli (E. coli) and Lactobacillus strains. The proposed mechanism of action of the Safranal-MIL-88B(Fe) nanostructures potentially shows the effect of the release of the ferric ions and Safranal in vitro against HepG2 cancer cells and both bacterial strains. Our findings show significant promise for Safranal-loaded MIL-88B(Fe) as a dual-purpose therapeutic agent, opening exciting avenues for future biomedical applications.

Graphical abstract: Synthesis and characterization of safranal@MIL-88B(Fe) nanostructures and their preliminary anticancer and antibacterial characteristics

Supplementary files

Article information

Article type
Paper
Submitted
31 3 2024
Accepted
04 7 2024
First published
05 7 2024
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2024,5, 6501-6515

Synthesis and characterization of safranal@MIL-88B(Fe) nanostructures and their preliminary anticancer and antibacterial characteristics

A. Alkaabi, K. Ahsan, N. Munawar, A. Samadi, H. El-Maghraby, A. Amin and Y. Greish, Mater. Adv., 2024, 5, 6501 DOI: 10.1039/D4MA00345D

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements