Issue 13, 2023

Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Abstract

Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and are safe and green, and rely on Nature-inspired thioesters that are then converted to the targeted functionality.

Graphical abstract: Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Supplementary files

Article information

Article type
Edge Article
Submitted
12 1 2023
Accepted
27 2 2023
First published
28 2 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2023,14, 3462-3469

Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green

Kaitlyn M. Freiberg, R. D. Kavthe, R. M. Thomas, D. M. Fialho, P. Dee, M. Scurria and B. H. Lipshutz, Chem. Sci., 2023, 14, 3462 DOI: 10.1039/D3SC00198A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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