Issue 36, 2023

On the way to potential antifungal compounds: synthesis and in vitro activity of 2-benzofuranylacetic acid amides

Abstract

Crop losses caused by microbial infections are a significant global issue, especially in tropical regions. The development of novel antimicrobial agents, particularly antifungal agents, has been explored from various perspectives, including chemical synthesis. However, conventional approaches typically involve synthesizing new and potent compounds on a small scale (a few milligrams), making the scale-up of the reaction a major challenge. In this manuscript, we present a method for the synthesis of new and active (against Fusarium oxysporum) benzofuranyl acetic acid amides. Our strategy allows us to synthesize the key precursor on the gram scale, enabling the production of sufficient quantities of other active compounds within short timeframes for conducting biological studies. All the reactions used in this manuscript are recognized by their industrial application.

Graphical abstract: On the way to potential antifungal compounds: synthesis and in vitro activity of 2-benzofuranylacetic acid amides

Supplementary files

Article information

Article type
Paper
Submitted
14 7 2023
Accepted
17 8 2023
First published
23 8 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 25296-25304

On the way to potential antifungal compounds: synthesis and in vitro activity of 2-benzofuranylacetic acid amides

C. Mahecha-Mahecha, P. Borrego-Muñoz, L. M. Pombo and D. Gamba-Sánchez, RSC Adv., 2023, 13, 25296 DOI: 10.1039/D3RA04737G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements