Issue 90, 2022

Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Abstract

The unique heterocyclic skeletons of N-heterocyclic phosphines (NHPs) endow them with excellent hydridic reactivity, which has enabled NHPs to be applied in a great array of catalytic hydrogenations of unsaturated substrates in the past few decades. Recently, applications of NHPs in radical reductions, especially in a catalytic fashion, have emerged as a promising forefront area. This new reaction pattern, distinctive from but complementary to the well-established hydride pathway, can greatly expand the reaction scope to σ-bond scission. Herein, we briefly summarized some representative examples of synthetic applications of NHPs in both hydridic and radical reductions with an emphasis on their radical reactivity, including the structural and property studies of NHP radicals and their precursors as well as their applications in radical processes.

Graphical abstract: Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Article information

Article type
Feature Article
Submitted
01 9 2022
Accepted
06 10 2022
First published
07 10 2022

Chem. Commun., 2022,58, 12528-12543

Synthetic applications of NHPs: from the hydride pathway to a radical mechanism

Y. Zhang, Z. Huan, J. Yang and J. Cheng, Chem. Commun., 2022, 58, 12528 DOI: 10.1039/D2CC04844B

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