Issue 7, 2021

Biomaterials for protein delivery for complex tissue healing responses

Abstract

Tissue repair requires a complex cascade of events mediated by a variety of cells, proteins, and matrix molecules; however, the healing cascade can be easily disrupted by numerous factors, resulting in impaired tissue regeneration. Recent advances in biomaterials for tissue regeneration have increased the ability to tailor the delivery of proteins and other biomolecules to injury sites to restore normal healing cascades and stimulate robust tissue repair. In this review, we discuss the evolution of the field toward creating biomaterials that precisely control protein delivery to stimulate tissue regeneration, with a focus on addressing complex and dynamic injury environments. We highlight biomaterials that leverage different mechanisms to deliver and present proteins involved in healing cascades, tissue targeting and mimicking strategies, materials that can be triggered by environmental cues, and integrated strategies that combine multiple biomaterial properties to improve protein delivery. Improvements in biomaterial design to address complex injury environments will expand our understanding of both normal and aberrant tissue repair processes and ultimately provide a better standard of patient care.

Graphical abstract: Biomaterials for protein delivery for complex tissue healing responses

Article information

Article type
Review Article
Submitted
23 10 2020
Accepted
30 12 2020
First published
12 1 2021

Biomater. Sci., 2021,9, 2339-2361

Biomaterials for protein delivery for complex tissue healing responses

J. Dorogin, J. M. Townsend and M. H. Hettiaratchi, Biomater. Sci., 2021, 9, 2339 DOI: 10.1039/D0BM01804J

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