Issue 45, 2020

Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers

Abstract

We describe a divergent and enantioselective total synthesis of (+)-ieodomycin A and (+)-ieodomycin B with three stereoisomers. The main advantage of the present synthesis is the late-stage elaboration of the side chain, which would afford a wide range of structurally diverse analogs with interesting bioactivities.

Graphical abstract: Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers

Supplementary files

Article information

Article type
Communication
Submitted
19 10 2020
Accepted
07 11 2020
First published
09 11 2020

Org. Biomol. Chem., 2020,18, 9227-9230

Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers

D. Choi, H. Choi, J. Lee, Y. Lee, H. Lee, J. M. Joo and J. S. Lee, Org. Biomol. Chem., 2020, 18, 9227 DOI: 10.1039/D0OB02107E

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