Issue 21, 2019

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Abstract

Herein we report an efficient manganese-catalyzed C-alkylation of unactivated amides and tert-butyl acetate using alcohols as alkylating agents. This elegant approach exhibits a broad substrate scope providing the C–C coupled products of amides via a hydrogen auto-transfer strategy using aryl, heteroaryl, and aliphatic alcohols.

Graphical abstract: Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

Supplementary files

Article information

Article type
Communication
Submitted
20 12 2018
Accepted
12 3 2019
First published
20 3 2019

Dalton Trans., 2019,48, 7094-7099

Manganese-catalyzed direct C–C coupling of α-C–H bonds of amides and esters with alcohols via hydrogen autotransfer

J. Rana, V. Gupta and E. Balaraman, Dalton Trans., 2019, 48, 7094 DOI: 10.1039/C8DT05020A

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