Issue 4, 2017

A mild catalytic system for radical conjugate addition of nitrogen heterocycles

Abstract

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.

Graphical abstract: A mild catalytic system for radical conjugate addition of nitrogen heterocycles

Supplementary files

Article information

Article type
Edge Article
Submitted
17 1 2017
Accepted
13 2 2017
First published
13 2 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 3121-3125

A mild catalytic system for radical conjugate addition of nitrogen heterocycles

R. A. Aycock, H. Wang and N. T. Jui, Chem. Sci., 2017, 8, 3121 DOI: 10.1039/C7SC00243B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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