Issue 5, 2017

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Abstract

The rational design and synthesis of a Trp-BODIPY cyclic peptide for the fluorescent labelling of apoptotic bodies is described. Affinity assays, confocal microscopy and flow cytometry analysis confirmed the binding of the peptide to negatively-charged phospholipids associated with apoptosis, and its applicability for the detection and characterisation of subcellular structures released by apoptotic cells.

Graphical abstract: A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

Supplementary files

Article information

Article type
Communication
Submitted
28 9 2016
Accepted
13 12 2016
First published
15 12 2016

Chem. Commun., 2017,53, 945-948

A Trp-BODIPY cyclic peptide for fluorescence labelling of apoptotic bodies

R. Subiros-Funosas, L. Mendive-Tapia, J. Sot, J. D. Pound, N. Barth, Y. Varela, F. M. Goñi, M. Paterson, C. D. Gregory, F. Albericio, I. Dransfield, R. Lavilla and M. Vendrell, Chem. Commun., 2017, 53, 945 DOI: 10.1039/C6CC07879F

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