Issue 66, 2016

Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

Abstract

Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.

Graphical abstract: Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

Article information

Article type
Feature Article
Submitted
07 6 2016
Accepted
28 6 2016
First published
29 6 2016
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2016,52, 10093-10108

Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents

F. Hof, Chem. Commun., 2016, 52, 10093 DOI: 10.1039/C6CC04771H

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