Issue 30, 2012

The direct catalytic asymmetric aldol reaction of α-substituted nitroacetates with aqueous formaldehyde under base-free neutral phase-transfer conditions

Abstract

Enantioselective direct aldol reaction of α-substituted nitroacetates with aqueous formaldehyde for the synthesis of α-alkyl serines has been achieved under base-free neutral phase-transfer conditions with a bifunctional chiral phase-transfer catalyst.

Graphical abstract: The direct catalytic asymmetric aldol reaction of α-substituted nitroacetates with aqueous formaldehyde under base-free neutral phase-transfer conditions

Supplementary files

Article information

Article type
Communication
Submitted
29 12 2011
Accepted
30 1 2012
First published
30 1 2012

Org. Biomol. Chem., 2012,10, 5753-5755

The direct catalytic asymmetric aldol reaction of α-substituted nitroacetates with aqueous formaldehyde under base-free neutral phase-transfer conditions

S. Shirakawa, K. Ota, S. J. Terao and K. Maruoka, Org. Biomol. Chem., 2012, 10, 5753 DOI: 10.1039/C2OB07193B

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