Issue 34, 2009

Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex

Abstract

A homodinuclear Ni2-Schiff base1 complex (0.1–1 mol%) promoted the direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde, giving hydroxymethylated adducts in 94–66% ee.

Graphical abstract: Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex

Supplementary files

Article information

Article type
Communication
Submitted
23 6 2009
Accepted
07 7 2009
First published
24 7 2009

Chem. Commun., 2009, 5138-5140

Direct catalytic asymmetric aldol reaction of β-keto esters with formaldehyde promoted by a dinuclear Ni2-Schiff base complex

S. Mouri, Z. Chen, S. Matsunaga and M. Shibasaki, Chem. Commun., 2009, 5138 DOI: 10.1039/B912380F

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