Issue 28, 2016

A G4·K+ hydrogel that self-destructs

Abstract

A G4-quartet based hydrogel formed by self-assembly of borate esters of 5′-deoxy-5′-iodoguanosine (5′-IG 2) undergoes in situ cyclization to give 5′-deoxy-N3,5′-cycloguanosine (5′-cG 3). Formation of 5′-cG 3 causes self-destruction of the gel. This intramolecular cyclization can be used to release nucleoside analogs that have been pre-incorporated into the gel network.

Graphical abstract: A G4·K+ hydrogel that self-destructs

Supplementary files

Article information

Article type
Communication
Submitted
18 2 2016
Accepted
07 3 2016
First published
09 3 2016

Chem. Commun., 2016,52, 5037-5040

A G4·K+ hydrogel that self-destructs

T. N. Plank and J. T. Davis, Chem. Commun., 2016, 52, 5037 DOI: 10.1039/C6CC01494A

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